Id: acc3862
Group: 1sens
Protein: ERK1
Gene Symbol: Mapk3
Protein Id: P21708
Protein Name: MK03_RAT
PTM: phosphorylation
Site: Thr202
Site Sequence: DPEHDHTGFLTEYVATRWYRA
Disease Category: Endocrine and metabolic diseases
Disease: Diabetes Mellitus
Disease Subtype:
Disease Cellline:
Disease Info:
Drug: streptozotocin + arjunolic acid
Drug Info: Streptozotocin is a chemotherapeutic agent used in the treatment of pancreatic cancer. | Arjunolic acid has various pharmacological activities such as anti - inflammatory and antioxidant properties.
Effect: modulate
Effect Info: "In our study, STZ exposure led to an increase in the immunoreactive concentrations of phosphorylated ERK, phosphorylated JNK, and phosphorylated p38 in diabetic spleen tissues, which could be reduced by AA treatment. However, treating animals with AA alone had no effect on the expression of phosphorylated MAPKs."
Note:
Score: 4.0
Pubmed(PMID): 20053369
Sentence Index:
Sentence:

Sequence & Structure:

MAAAAAAPGGGGGEPRGTAGVVPVVPGEVEVVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRAPTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFDMELDDLPKERLKELIFQETARFQPGAPEAP

No data.

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets

No data.

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD
Residue Position State Disease Class PMID
T 203 D Major depressive disorder Phosphorylation 16959794
Y 205 D Major depressive disorder Phosphorylation 16959794
T 203 U Uteroplacental insufficiency Phosphorylation 16940436
Y 205 U Uteroplacental insufficiency Phosphorylation 16940436

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: