Id: acc3901
Group: 1sens
Protein: PPARgamma
Gene Symbol: Pparg
Protein Id: P37238
Protein Name: PPARG_MOUSE
PTM: phosphorylation
Site: Ser273
Site Sequence: ILTGKTTDKSPFVIYDMNSLM
Disease Category: Endocrine and metabolic diseases
Disease: Obese
Disease Subtype: insulin resistance
Disease Cellline:
Disease Info:
Drug: rosiglitazone
Drug Info: Rosiglitazone is a thiazolidinedione antidiabetic drug that works by improving insulin sensitivity.
Effect: modulate
Effect Info: Rosiglitazone inhibits PPARγ phosphorylation in obese patients and alleviates insulin resistance.
Note:
Score: 4.0
Pubmed(PMID): 20651683
Sentence Index:
Sentence:

Sequence & Structure:

MGETLGDSPVDPEHGAFADALPMSTSQEITMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISAPHYEDIPFTRADPMVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNRPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKNIPGFINLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKNLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKVLQKMTDLRQIVTEHVQLLHVIKKTETDMSLHPLLQEIYKDLY

No data.

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets

No data.

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD
Residue Position State Disease Class PMID
S 273 U Hepatitis Phosphorylation 30008738

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: