| Id: | acc3905 |
| Group: | 1sens |
| Protein: | TAK-1 |
| Gene Symbol: | Map3k7 |
| Protein Id: | P0C8E4 |
| Protein Name: | M3K7_RAT |
| PTM: | phosphorylation |
| Site: | Ser412 |
| Site Sequence: | TAYTKPKRGHRKTASFGNILD |
| Disease Category: | Infectious diseases |
| Disease: | Endotoxemic |
| Disease Subtype: | |
| Disease Cellline: | H9c2 |
| Disease Info: | |
| Drug: | Thaliporphine |
| Drug Info: | Thaliporphine is a drug with potential pharmacological effects. It may be used in relevant medical research and treatment. |
| Effect: | modulate |
| Effect Info: | Saliporphine improves cardiac depression in rats with endotoxemia by attenuating TLR4 signaling downstream of TAK-1 phosphorylation and NF-κB signaling. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 20848273 |
| Sentence Index: | 20848273_10 |
| Sentence: | "In conclusion, thaliporphine ameliorates LPS-induced cardiac depression through attenuating TLR4 signaling in the downstream of TAK-1 phosphorylation and NF-kappaB signaling in both cardiomyocytes and macrophage to prevent cardiac SERCA2 from nitrosylation by peroxynitrite via decreasing iNOS and TNF-alpha expression." |
Sequence & Structure:
MSTASAASSSSSSSASEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQSDSGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIVATTAYTKPKRGHRKTASFGNILDVPEIVISGNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPARSLPWTPDDSTDTNGSDNSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQEYMKVQTEIALLLQRKQELVAELDQDEKDQQNTSRLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQKRQGTS
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
