| Id: | acc3923 |
| Group: | 1sens |
| Protein: | GATA3 |
| Gene Symbol: | Gata3 |
| Protein Id: | P23772 |
| Protein Name: | GATA3_MOUSE |
| PTM: | phosphorylation |
| Site: | unclear |
| Site Sequence: | |
| Disease Category: | Immune system diseases |
| Disease: | Asthma |
| Disease Subtype: | allergic airway inflammation |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | Florfenicol |
| Drug Info: | Florfenicol is a broad - spectrum antibiotic commonly used in veterinary medicine to treat a variety of bacterial infections. |
| Effect: | modulate |
| Effect Info: | Florfenicol significantly inhibited the infiltration of inflammatory cells in lung tissue and the hyperplasia of airway acinar cells induced by ovalbumin. Its mechanism of action may be related to the inhibition of p38 MAPK-mediated phosphorylation of GATA 3. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 21163707 |
| Sentence Index: | 21163707_0 |
| Sentence: | Florfenicol inhibits allergic airway inflammation in mice by p38 MAPK-mediated phosphorylation of GATA 3. |
Sequence & Structure:
MEVTADQPRWVSHHHPAVLNGQHPDTHHPGLGHSYMEAQYPLTEEVDVLFNIDGQGNHVPSYYGNSVRATVQRYPPTHHGSQVCRPPLLHGSLPWLDGGKALSSHHTASPWNLSPFSKTSIHHGSPGPLSVYPPASSSSLAAGHSSPHLFTFPPTPPKDVSPDPSLSTPGSAGSARQDEKECLKYQVQLPDSMKLETSHSRGSMTTLGGASSSAHHPITTYPPYVPEYSSGLFPPSSLLGGSPTGFGCKSRPKARSSTEGRECVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTSCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNINRPLTMKKEGIQTRNRKMSSKSKKCKKVHDALEDFPKSSSFNPAALSRHMSSLSHISPFSHSSHMLTTPTPMHPPSGLSFGPHHPSSMVTAMG
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
