| Id: | acc3963 |
| Group: | 1sens |
| Protein: | GATA4 |
| Gene Symbol: | Gata4 |
| Protein Id: | Q08369 |
| Protein Name: | GATA4_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser105 |
| Site Sequence: | GAAYTPPPVSPRFSFPGTTGS |
| Disease Category: | Cardiovascular and circulatory system diseases |
| Disease: | Systolic Dysfunction |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | PD98059 |
| Drug Info: | PD98059 is a well - known drug that has been used in various research studies related to cell signaling pathways. |
| Effect: | modulate |
| Effect Info: | "Hyperglycemia → increased ROS → increased MEK/ERK → increased phosphorylation of GATA - 4 → increased nuclear transcriptional activity → increased cTnI expression → impaired systolic function. These changes can be reversed by ilmenite (ROS scavenger), PD98059 (MEK/ERK inhibitor), or siRNA of GATA - 4. Diabetic cardiomyopathy refers to a disease that ultimately leads to left ventricular hypertrophy and diastolic and systolic dysfunction. The authors' research on systolic dysfunction is not directly related to the disease. " |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 21702924 |
| Sentence Index: | 21702924_17 |
| Sentence: | "CONCLUSIONS: Hyperglycemia can cause systolic dysfunction and a higher expression of cTnI in cardiomyocytes through ROS, enhancing MEK/ERK-induced GATA-4 phosphorylation and accumulation in the cell nucleus." |
Sequence & Structure:
MYQSLAMAANHGPPPGAYEAGGPGAFMHSAGAASSPVYVPTPRVPSSVLGLSYLQGGGSAAAAGTTSGGSSGAGPSGAGPGTQQGSPGWSQAGAEGAAYTPPPVSPRFSFPGTTGSLAAAAAAAAAREAAAYGSGGGAAGAGLAGREQYGRPGFAGSYSSPYPAYMADVGASWAAAAAASAGPFDSPVLHSLPGRANPGRHPNLDMFDDFSEGRECVNCGAMSTPLWRRDGTGHYLCNACGLYHKMNGINRPLIKPQRRLSASRRVGLSCANCQTTTTTLWRRNAEGEPVCNACGLYMKLHGVPRPLAMRKEGIQTRKRKPKNLNKSKTPAGPAGETLPPSSGASSGNSSNATSSSSSSEEMRPIKTEPGLSSHYGHSSSMSQTFSTVSGHGPSIHPVLSALKLSPQGYASPVTQTSQASSKQDSWNSLVLADSHGDIITA
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
