| Id: | acc4004 |
| Group: | 1sens |
| Protein: | ERK |
| Gene Symbol: | Mapk3 |
| Protein Id: | Q63844 |
| Protein Name: | MK03_MOUSE |
| PTM: | phosphorylation |
| Site: | Tyr204 |
| Site Sequence: | EHDHTGFLTEYVATRWYRAPE |
| Disease Category: | Nervous system diseases |
| Disease: | Memory Retrieval |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | diazepam |
| Drug Info: | "Diazepam is a benzodiazepine drug commonly used to treat anxiety, insomnia, and muscle spasms. It works by enhancing the effects of a neurotransmitter called gamma - aminobutyric acid (GABA) in the brain. " |
| Effect: | modulate |
| Effect Info: | "GABA(A) receptor agonists (such as Muscimol and diazepam) inhibit ERK phosphorylation, leading to impaired memory retrieval. In contrast, GABA(A) receptor antagonists (such as BMI) promote ERK phosphorylation and memory retrieval." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 22169949 |
| Sentence Index: | 22169949_8 |
| Sentence: | "Furthermore, co-treatment with sub-effective dose of U0126, a mitogen-activated protein kinase inhibitor, blocked the upregulation of ERK phosphorylation and impaired memory retrieval, and bicuculline methiodide (BMI), a GABA(A) receptor antagonist, increased ERK phosphorylation induced by the retention trial and facilitated memory retrieval." |
Sequence & Structure:
MAAAAAAPGGGGGEPRGTAGVVPVVPGEVEVVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRAPTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFDMELDDLPKERLKELIFQETARFQPGAPEGP
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMD| Residue | Position | State | Disease | Class | PMID |
|---|---|---|---|---|---|
| T | 203 | U | Squamous cell carcinoma | Phosphorylation | 19934324 |
State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
