Id: acc4011
Group: 1sens
Protein: STAT1
Gene Symbol: STAT1
Protein Id: P42224
Protein Name: STAT1_HUMAN
PTM: phosphorylation
Site: Tyr701
Site Sequence: ELDGPKGTGYIKTELISVSEV
Disease Category: Digestive system diseases
Disease: Chronic Hepatitis C
Disease Subtype:
Disease Cellline: cynomolgus monkey hepatocytes
Disease Info:
Drug: pegIFNlambda
Drug Info: PegIFNlambda is a drug. It may be used in certain medical treatments.
Effect: modulate
Effect Info: Pegylated interferon lambda - 1 (pegIFNλ) induces the expression of interferon - stimulated genes (ISG) by selectively activating the phosphorylation of STAT1 in hepatocytes.
Note:
Score: 4.0
Pubmed(PMID): 22280056
Sentence Index:
Sentence:

Sequence & Structure:

MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQRFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNREHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWKRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQVLWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKVKVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAEPRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWTRFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFLLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTTDNLLPMSPEEFDEVSRIVGSVEFDSMMNTV

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets
Small molecule
Antibody
PROTAC
Other modalities
Approved Drug
Advanced Clinical
Phase 1 Clinical
Structure with Ligand
High-Quality Ligand
High-Quality Pocket
Med-Quality Pocket
Druggable Family
Approved Drug
Advanced Clinical
Phase 1 Clinical
UniProt loc high conf
GO CC high conf
UniProt loc med conf
UniProt SigP or TMHMM
GO CC med conf
Human Protein Atlas loc
Approved Drug
Advanced Clinical
Phase 1 Clinical
Literature
UniProt Ubiquitination
Database Ubiquitination
Half-life Data
Small Molecule Binder
Approved Drug
Advanced Clinical
Phase 1 Clinical

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD
Residue Position State Disease Class PMID
Y 701 D Melanoma Phosphorylation 17785551
Y 701 U Breast cancer/tumor/carcinoma Phosphorylation 24058806
Y 701 U Secondary hemophagocytic lymphohistiocytosis/macrophage activation syndrome Phosphorylation 33815425

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM
Protein Gene PTM Position Modified sequence Cell Drug pEC50 Regulation Experiment
P42224 STAT1 P Tyr701 GTGY(ph)IK ARH-77 Rituximab -0.6427 down
P42224 STAT1 P Tyr701 GTGY(ph)IK ARH-77 Rituximab -1.7733 -
P42224 STAT1 P Tyr701 GTGY(ph)IK ARH-77 Rituximab -0.8673 -
P42224 STAT1 P Tyr701 GTGY(ph)IK ARH-77 Rituximab -3.5049 -
P42224 STAT1 P Tyr701 GTGY(ph)IK ARH-77 Rituximab -1.2234 -
P42224 STAT1 P Tyr701 GTGY(ph)IK ARH-77 Rituximab -3.8772 -
P42224 STAT1 P Tyr701 GTGY(ph)IK ARH-77 Rituximab -2.9951 -
P42224 STAT1 P Tyr701 GTGY(ph)IK ARH-77 Rituximab -1.6009 -

pEC50 Note: pEC50 is the negative logarithm of EC50 (half-maximal effective concentration, dosage unit Mol), calculated as pEC50 = -log10(EC50), which quantifies the potency of a drug or compound.

Function score:

source: funscoR

No data.

Cross Links: