| Id: | acc4018 |
| Group: | 1sens |
| Protein: | AMPK |
| Gene Symbol: | Prkaa1 |
| Protein Id: | P54645 |
| Protein Name: | AAPK1_RAT |
| PTM: | phosphorylation |
| Site: | Thr183 |
| Site Sequence: | MMSDGEFLRTSCGSPNYAAPE |
| Disease Category: | Endocrine and metabolic diseases |
| Disease: | Polycystic Ovarian Syndrome |
| Disease Subtype: | |
| Disease Cellline: | granulosa cells |
| Disease Info: | |
| Drug: | DHT |
| Drug Info: | "DHT, or dihydrotestosterone, is a male sex hormone that plays a crucial role in the development of male characteristics." |
| Effect: | modulate |
| Effect Info: | "DHT-activated AMPK reduces granulosa cell proliferation by inhibiting ERK phosphorylation, which may be associated with ovulatory dysfunction in polycystic ovary syndrome (PCOS)." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 22454147 |
| Sentence Index: | 22454147_11 |
| Sentence: | "Thus, inhibition of ERK phosphorylation by activated AMPK in response to DHT might contribute to decreased granulosa cell mitogenesis and ovulatory dysfunction seen in hyperandrogenic states." |
Sequence & Structure:
MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSISNYRSCQRSDSDAEAQGKPSEVSLTSSVTSLDSSPVDVAPRPGSHTIEFFEMCANLIKILAQ
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
