| Id: | acc4023 |
| Group: | 1sens |
| Protein: | JNK1 |
| Gene Symbol: | Mapk8 |
| Protein Id: | Q91Y86 |
| Protein Name: | MK08_MOUSE |
| PTM: | phosphorylation |
| Site: | Tyr185 |
| Site Sequence: | AGTSFMMTPYVVTRYYRAPEV |
| Disease Category: | Nervous system diseases |
| Disease: | Cognitive Abnormalities |
| Disease Subtype: | Cognitive Deficits |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | domoic acid |
| Drug Info: | Domoic acid is a neurotoxin produced by certain marine algae. It can cause amnesic shellfish poisoning in humans when consumed through contaminated shellfish. |
| Effect: | modulate |
| Effect Info: | "Kainic acid promotes the phosphorylation of p47phox by activating PKC-ζ, which in turn activates the phosphorylation of JNK and inhibits the phosphorylation of FoxO1, ultimately leading to neuronal apoptosis and cognitive deficits." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 22474074 |
| Sentence Index: | 22474074_7 |
| Sentence: | "In turn, the abnormal ROS levels in the hippocampus of DA-treated mice activated SAPK/JNK pathway, decreased FoxO1 phosphorylation, stimulated the nuclear translocation of FoxO1, activated FasL/Fas signaling, and promoted the activation of caspase-8 and caspase-3, which resulted in neuron apoptosis and cognitive deficits in mice." |
Sequence & Structure:
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEERTKNGVIRGQPSPLAQVQQ
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
