| Id: | acc4035 |
| Group: | 1sens |
| Protein: | NR1 |
| Gene Symbol: | Gprin1 |
| Protein Id: | Q3UNH4 |
| Protein Name: | GRIN1_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser890 |
| Site Sequence: | PPPAVRAGPGRAGSVRTAPAE |
| Disease Category: | Nervous system diseases |
| Disease: | Painful Diabetic Neuropathy |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | MK801? |
| Drug Info: | "MK801 is a non - competitive antagonist of the N - methyl - D - aspartate (NMDA) receptor, often used in neuroscience research." |
| Effect: | modulate |
| Effect Info: | "Phosphorylation of the NMDAR-NR1 subunit is involved in the increase of neuronal excitability and pain maintenance, and is inhibited by MK801 and the NOS inhibitor L-NAME." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 22573263 |
| Sentence Index: | 22573263_8 |
| Sentence: | "Treatment with MK801, an NMDAR inhibitor, inhibited mechanical allodynia, ERK1/2 phosphorylation, and nNOS and iNOS upregulation in diabetic mice." |
Sequence & Structure:
MRDCCSSPKAIPAPPRHALDQSLGMDPRHTSSSGAAEGASCSERPAGSLACPSPNCSPLPETPRAHGALTSDNSGTTLFGKPEPMSSAEATPTASEIRNPVFSGKMDGNSLKQADSTSTRKEEAGSLRNEESMLKGKAEPMIYGKGEPGTVGRVDCTASGAENSGSLGKVDMPCSSKVDIVSPGGDNAGSLRKVETISSGKMDPKTENVMHSRRERPGSTGEGDLVSLRENDMKPPDNTDSASTKKTDPEFSGKLTPGSSGKTELVSSVTVAPVTSENVNPVCSGGAGPAAVGNSETLSSVKKDPQLLGKKEAVSSGEGGSVSVRMAETVSARQPEGMFPAKTDSTSSNSTGPSGRADPVSLRNSELVSPVKPERLSSGQAERVSLVKTETLSSGKEDPRSSRRVDHTTVTGNMQTSQKGNPESSGKTDLGSSSSGDTRSLGTWGSLSAAKAEVTEGKGDPQPWKKASLPASEKTDPLASSKAGSASQGKAETVSPGEVDAMTLGKTVPTSSGKTALVSPGKVDLMTSERAEGIPELQASEKGNPVNSTRVDTGATGSTEPKSGVKVITQIPGATSPGKVETPSLQKEQPQLSEKTDPSRKVDPPTTVEPVSLGKADSASPSPRKAESQTSAKTVPQAPDKATSSLRQSDGTPYSSAQPQRDTRSIGSLPEREPSASTSQKDLAAAAAQKSPSAEAAAPPPGPRTRDNFTKAPSWDAGAPPPREDAGTQAGAQACVSVAVSPMSPQDGAGGPAFSFQAAPRAPSPAPRPPSRRDAGLQVSLGAAETRSVATGPMTPQAAAPPAVPPVFPEVRVRPGSVLAAALAPQEATEPVRDVSWDEKGMTWEVYGASMEVEVLGMAIQKHLERQIEEHGRQGAPAPAPPPAVRAGPGRAGSVRTAPAEGAAKRPPGLFRALLQSVRRPRCCSRAGPTAE
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
