| Id: | acc4038 |
| Group: | 1sens |
| Protein: | FOXO3a |
| Gene Symbol: | Foxo3 |
| Protein Id: | Q9WVH4 |
| Protein Name: | FOXO3_MOUSE |
| PTM: | phosphorylation |
| Site: | Thr32 |
| Site Sequence: | EPQSRPRSCTWPLQRPELQAS |
| Disease Category: | Endocrine and metabolic diseases |
| Disease: | Diabetes Mellitus |
| Disease Subtype: | STZ induced diabetic mice |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | GW501516ruboxistaurin |
| Drug Info: | GW501516 is a PPARδ agonist with potential effects on metabolism and endurance. Ruboxistaurin is a protein kinase C beta inhibitor used in the treatment of diabetic complications. |
| Effect: | modulate |
| Effect Info: | "The PKCβ inhibitor ruboxistaurin or the peroxisome proliferator-activated receptor δ agonist GW501516 can reduce atrogin–1 expression, increase AKT and FOXO-3a phosphorylation, and restore coronary vasodilation function in diabetic mice." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 22586590 |
| Sentence Index: | 22586590_6 |
| Sentence: | "Using cellular biology, patch clamp, and videomicroscopy techniques, we found that reduced BK-beta(1) expression in streptozotocin (STZ)-induced diabetic mouse arteries and in human coronary smooth muscle cells (SMCs) cultured with high glucose was attributable to an increase in protein kinase C (PKC)-beta and NADPH oxidase expressions and accompanied by attenuation of Akt phosphorylation and augmentation of atrogin-1 expression." |
Sequence & Structure:
MAEAPASPVPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEEDDDEDDEDGGGRASSAMVIGGGVSSTLGSGLLLEDSAMLLAPGGQDLGSGPASAAGALSGGTPTQLQPQQPLPQPQPGAAGGSGQPRKCSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFMRVQNEGTGKSSWWIINPDGGKSGKAPRRRAVSMDNSNKYTKSRGRAAKKKAALQAAPESADDSPSQLSKWPGSPTSRSSDELDAWTDFRSRTNSNASTVSGRLSPILASTELDDVQDDDGPLSPMLYSSSASLSPSVSKPCTVELPRLTDMAGTMNLNDGLAENLMDDLLDNIALPPSQPSPPGGLMQRGSSFPYTAKSSGLGSPTGSFNSTVFGPSSLNSLRQSPMQTIQENRPATFSSVSHYGNQTLQDLLASDSLSHSDVMMTQSDPLMSQASTAVSAQNARRNVMLRNDPMMSFAAQPTQGSLVNQNLLHHQHQTQGALGGSRALSNSVSNMGLSDSSSLGSAKHQQQSPASQSMQTLSDSLSGSSLYSASANLPVMGHDKFPSDLDLDMFNGSLECDMESIIRSELMDADGLDFNFDSLISTQNVVGLNVGNFTGAKQASSQSWVPG
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
