| Id: | acc4064 |
| Group: | 1sens |
| Protein: | CREB |
| Gene Symbol: | Creb1 |
| Protein Id: | P15337 |
| Protein Name: | CREB1_RAT |
| PTM: | phosphorylation |
| Site: | Ser133 |
| Site Sequence: | LNDLSSDAPGVPRIEEEKSEE |
| Disease Category: | Endocrine and metabolic diseases |
| Disease: | Chronic Hyperlipidemia |
| Disease Subtype: | type 2 diabetes |
| Disease Cellline: | INS-1E |
| Disease Info: | |
| Drug: | kaempferol |
| Drug Info: | Kaempferol is a flavonoid commonly found in various plants and has antioxidant and anti - inflammatory properties. |
| Effect: | modulate |
| Effect Info: | Kaempferol enhances β-cell survival and function by upregulating CREB phosphorylation. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 22819546 |
| Sentence Index: | 22819546_7 |
| Sentence: | "Chronic hyperlipidemia significantly diminished cyclic adenosine monophosphate (cAMP) production, protein kinase A (PKA) activation, cAMP-responsive element binding protein (CREB) phosphorylation and its regulated transcriptional activity in beta-cells, all of which were restored by kaempferol treatment." |
Sequence & Structure:
MTMDSGADNQQSGDAAVTEAESQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPNGQTVQVHGVIQAAQPSVIQSPQVQTVQISTIAESEDSQESVDSVTDSQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSGQYIAITQGGAIQLANNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQVVVQAASGDVQTYQIRTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKSD
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMD| Residue | Position | State | Disease | Class | PMID |
|---|---|---|---|---|---|
| S | 133 | U | Pulmonary hypertension | Phosphorylation | 34635097 |
State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
