| Id: | acc4065 |
| Group: | 1sens |
| Protein: | IkappaBalpha |
| Gene Symbol: | Nkiras1 |
| Protein Id: | Q8CEC5 |
| Protein Name: | KBRS1_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser32 |
| Site Sequence: | QLLYGNHTIGMEDCETLEDVY |
| Disease Category: | Cardiovascular and circulatory system diseases |
| Disease: | Cardiac Dysfunction |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | Rhynchophylline |
| Drug Info: | Rhynchophylline is a natural indole alkaloid that can be extracted from certain plants and has potential pharmacological activities. |
| Effect: | modulate |
| Effect Info: | Rhynchophylline prevents cardiac dysfunction and improves the survival rate of lipopolysaccharide-challenged mice by inhibiting the phosphorylation of I-κBα in macrophages. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 22841535 |
| Sentence Index: | 22841535_9 |
| Sentence: | "These results indicate that Rhy reduces cardiac dysfunction and improves survival via suppression of macrophage I-kappaBalpha phosphorylation in LPS-challenged mice, and suggest that Rhy may be a potential agent for the treatment of septic cardiac dysfunction." |
Sequence & Structure:
MGKGCKVVICGLLSVGKTAILEQLLYGNHTIGMEDCETLEDVYMASVETDRGVKEQLHLYDTRGLQKGVELPKHYFSFADGFVLVYSVNNLESFQRVELLKKEIDKFKDKKEVAIVVLGNKLDLSEQRQVDADVAQQWARSEKVKLWEVTVTDRRTLIEPFTLLASKLSQPQSKSSFPLPGRKNKGNSNPEN
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
