| Id: | acc4074 |
| Group: | 1sens |
| Protein: | MEK |
| Gene Symbol: | MAP2K1 |
| Protein Id: | P31938 |
| Protein Name: | MP2K1_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser221 |
| Site Sequence: | SGQLIDSMANSFVGTRSYMSP |
| Disease Category: | Digestive system diseases |
| Disease: | Pancreatitis |
| Disease Subtype: | Chronic pancreatitis |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | Sulindac |
| Drug Info: | "Sulindac is a non - steroidal anti - inflammatory drug (NSAID) used to relieve pain, swelling, and inflammation." |
| Effect: | modulate |
| Effect Info: | "When Sulindac was used to treat chronic pancreatic tissue, it significantly inhibited the phosphorylation levels of MEK and ERK, indicating that the drug may exert its therapeutic effect by reducing the activity of the MEK/ERK signaling pathway." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 22920325 |
| Sentence Index: | 22920325_5 |
| Sentence: | The protein expression of phosphorylation of MEK/ERK was inhibited in the chronic pancreatic tissues by sulindac treatment as measured by Western blot assay. |
Sequence & Structure:
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELLFGCHVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAASI
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
