| Id: | acc4076 |
| Group: | 1sens |
| Protein: | ERK |
| Gene Symbol: | Mapk3 |
| Protein Id: | Q63844 |
| Protein Name: | MK03_MOUSE |
| PTM: | phosphorylation |
| Site: | Tyr204 |
| Site Sequence: | EHDHTGFLTEYVATRWYRAPE |
| Disease Category: | Endocrine and metabolic diseases |
| Disease: | Diabetes Mellitus |
| Disease Subtype: | Endothelial dysfunction |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | resveratrol + SB203580 |
| Drug Info: | Resveratrol is a natural polyphenol with various health - promoting properties | SB203580 is a selective inhibitor of p38 mitogen - activated protein kinase. |
| Effect: | modulate |
| Effect Info: | "Resveratrol (an Erk activator) can increase Erk phosphorylation, as well as shear stress-induced endothelial nitric oxide synthase (eNOS) phosphorylation and activity in 9-month-old diabetic mice. However, resveratrol alone cannot improve shear stress-induced dilation (SSID). The combined use of resveratrol and the p38/JNK inhibitor SB203580 (or SP600125) can significantly improve SSID in 9-month-old diabetic mice, and the Erk inhibitor U0126 can block this improvement effect." |
| Note: | drug comb |
| Score: | 4.0 |
| Pubmed(PMID): | 22933112 |
| Sentence Index: | 22933112_6 |
| Sentence: | "Treating the vessels of 9M diabetic mice with resveratrol increased Erk phosphorylation and shear stress-induced endothelial nitric oxide synthase (eNOS) phosphorylation and activity, but resveratrol alone did not improve SSID." |
Sequence & Structure:
MAAAAAAPGGGGGEPRGTAGVVPVVPGEVEVVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRAPTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFDMELDDLPKERLKELIFQETARFQPGAPEGP
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMD| Residue | Position | State | Disease | Class | PMID |
|---|---|---|---|---|---|
| T | 203 | U | Squamous cell carcinoma | Phosphorylation | 19934324 |
State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
