Id: acc4089
Group: 1sens
Protein: ERK1
Gene Symbol: Mapk3
Protein Id: P21708
Protein Name: MK03_RAT
PTM: phosphorylation
Site: Tyr204
Site Sequence: EHDHTGFLTEYVATRWYRAPE
Disease Category: Cardiovascular and circulatory system diseases
Disease: Myocardial I/R Injury
Disease Subtype:
Disease Cellline:
Disease Info:
Drug: Danshensu
Drug Info: Danshensu is a natural compound often extracted from traditional Chinese medicine. It has shown potential in cardiovascular protection.
Effect: modulate
Effect Info: The drug increases ERK phosphorylation and inhibits cardiomyocyte apoptosis.
Note:
Score: 4.0
Pubmed(PMID): 23200898
Sentence Index:
Sentence:

Sequence & Structure:

MAAAAAAPGGGGGEPRGTAGVVPVVPGEVEVVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRAPTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFDMELDDLPKERLKELIFQETARFQPGAPEAP

No data.

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets

No data.

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD
Residue Position State Disease Class PMID
T 203 D Major depressive disorder Phosphorylation 16959794
Y 205 D Major depressive disorder Phosphorylation 16959794
T 203 U Uteroplacental insufficiency Phosphorylation 16940436
Y 205 U Uteroplacental insufficiency Phosphorylation 16940436

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: