Id: acc4092
Group: 1sens
Protein: ESR1
Gene Symbol: ESR1
Protein Id: P03372
Protein Name: ESR1_HUMAN
PTM: methylation
Site: unclear
Site Sequence:
Disease Category: Cancer
Disease: Colorectal Cancer
Disease Subtype: adenoma
Disease Cellline:
Disease Info:
Drug: folate
Drug Info: Folate is a B - vitamin that is crucial for cell growth and metabolism. It also plays a key role in preventing certain birth defects.
Effect: no effect
Effect Info: Folic acid had no significant effect on the methylation of ESR1 and MLH1.
Note: no effect
Score: 2.0
Pubmed(PMID): 23328702
Sentence Index:
Sentence:

Sequence & Structure:

MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

Target Drug name MOA Phase Status Disease Source
ESR1 TOREMIFENE CITRATE Estrogen receptor modulator 4 - breast carcinoma DailyMed
DailyMed
ESR1 FULVESTRANT Estrogen receptor antagonist 4 - breast carcinoma DailyMed
ESR1 CLOMIPHENE CITRATE Estrogen receptor alpha modulator 4 - infertility DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
ESR1 CLOMIPHENE CITRATE Estrogen receptor alpha modulator 4 Completed infertility ClinicalTrials
ClinicalTrials
ESR1 CLOMIPHENE CITRATE Estrogen receptor alpha modulator 4 Unknown status infertility ClinicalTrials
ClinicalTrials
ClinicalTrials
ClinicalTrials
ClinicalTrials
ClinicalTrials
ESR1 DIETHYLSTILBESTROL DIPHOSPHATE Estrogen receptor agonist 4 - neoplasm ATC
ESR1 POLYESTRADIOL PHOSPHATE Estrogen receptor alpha agonist 4 - neoplasm ATC
ESR1 FULVESTRANT Estrogen receptor antagonist 4 - neoplasm ATC
ESR1 ETHINYL ESTRADIOL Estrogen receptor alpha agonist 4 - neoplasm ATC
ESR1 TAMOXIFEN Estrogen receptor alpha modulator 4 - neoplasm ATC
ESR1 DIETHYLSTILBESTROL Estrogen receptor alpha agonist 4 - neoplasm ATC
ESR1 CLOMIPHENE CITRATE Estrogen receptor alpha modulator 4 - polycystic ovary syndrome DailyMed
ESR1 CLOMIPHENE CITRATE Estrogen receptor alpha modulator 4 Completed polycystic ovary syndrome ClinicalTrials
ClinicalTrials
ClinicalTrials
ClinicalTrials
ESR1 CLOMIPHENE CITRATE Estrogen receptor alpha modulator 4 Terminated polycystic ovary syndrome ClinicalTrials
ESR1 CLOMIPHENE CITRATE Estrogen receptor alpha modulator 4 Unknown status polycystic ovary syndrome ClinicalTrials
ClinicalTrials
ESR1 ESTETROL Estrogen receptor agonist 4 - pregnancy FDA
ESR1 ESTROPIPATE Estrogen receptor alpha agonist 4 - osteoporosis DailyMed
ESR1 ESTROGENS, CONJUGATED Estrogen receptor agonist 4 - osteoporosis DailyMed
ESR1 FULVESTRANT Estrogen receptor antagonist 4 - breast neoplasm EMA
ESR1 FULVESTRANT Estrogen receptor antagonist 4 Terminated breast neoplasm ClinicalTrials
ESR1 ELACESTRANT HYDROCHLORIDE Estrogen receptor alpha degrader 4 - breast neoplasm FDA
ESR1 ESTRADIOL Estrogen receptor alpha agonist 4 - osteoporosis DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
ESR1 ESTRADIOL Estrogen receptor alpha agonist 4 - postmenopausal osteoporosis DailyMed
DailyMed
DailyMed
ESR1 LASOFOXIFENE TARTRATE Estrogen receptor modulator 4 - postmenopausal osteoporosis EMA
ESR1 ESTROGENS, CONJUGATED Estrogen receptor agonist 4 - postmenopausal osteoporosis DailyMed
DailyMed
DailyMed

Note: Only show clinically investigational or approved drugs with protein targets.

Protein Tractability:

source: Open Targets
Small molecule
Antibody
PROTAC
Other modalities
Approved Drug
Advanced Clinical
Phase 1 Clinical
Structure with Ligand
High-Quality Ligand
High-Quality Pocket
Med-Quality Pocket
Druggable Family
Approved Drug
Advanced Clinical
Phase 1 Clinical
UniProt loc high conf
GO CC high conf
UniProt loc med conf
UniProt SigP or TMHMM
GO CC med conf
Human Protein Atlas loc
Approved Drug
Advanced Clinical
Phase 1 Clinical
Literature
UniProt Ubiquitination
Database Ubiquitination
Half-life Data
Small Molecule Binder
Approved Drug
Advanced Clinical
Phase 1 Clinical

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD
Residue Position State Disease Class PMID
- - P Breast cancer/tumor/carcinoma Ubiquitination 24125069
- - P Breast cancer/tumor/carcinoma Methylation 2733079
S - P Breast cancer/tumor/carcinoma Phosphorylation 23946788
S - P Breast cancer/tumor/carcinoma Phosphorylation 22733972
- - P Breast cancer Ubiquitination 31518603
- - U Breast cancer Ubiquitination 32599554
- - U Breast cancer/tumor/carcinoma Methylation 18647968
- - U Breast cancer Ubiquitination 36271315
- - U Breast cancer Ubiquitination 34645792
- - U Breast cancer Ubiquitination 33771975
- - U Breast cancer Ubiquitination 34035221
- - U Endometrial cancer Ubiquitination 36423684
- - U Breast cancer Ubiquitination 36221793
- - U Breast cancer Ubiquitination 35392925
- - U Breast cancer Ubiquitination 32973333
S - U Breast cancer/tumor/carcinoma Phosphorylation 24051437
- - U Breast cancer/tumor/carcinoma Methylation 3917730
- - U Breast cancer/tumor/carcinoma Methylation 24649078

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: