| Id: | acc4094 |
| Group: | 1sens |
| Protein: | CaMKIV |
| Gene Symbol: | Camk4 |
| Protein Id: | P13234 |
| Protein Name: | KCC4_RAT |
| PTM: | phosphorylation |
| Site: | unclear |
| Site Sequence: | |
| Disease Category: | Cardiovascular and circulatory system diseases |
| Disease: | Infarction |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | Tat-NR2B9c |
| Drug Info: | Tat - NR2B9c is a drug that may have potential effects in relevant medical fields. Its specific functions and applications may require further research and exploration. |
| Effect: | modulate |
| Effect Info: | "In the cerebral ischemia model, Tat-NR2B9c can selectively and persistently enhance the phosphorylation level of CaMKIV, thereby significantly reducing the volume of cerebral infarction and exhibiting neuroprotective effects." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 23363435 |
| Sentence Index: | 23363435_7 |
| Sentence: | Tat-NR2B9c application significantly reduces infarct size and causes a selective and sustained elevation in CaMKIV phosphorylationation; effects which are blocked by coadministration of KN93. |
Sequence & Structure:
MLKVTVPSCPSSPCSSVTSSTENLVPDYWIDGSKRDPLSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVKKLIVLDPKKRLTTFQALQHPWVTGKAANFVHMDTAQKKLQEFNARRKLKAAVKAVVASSRLGSASSSHTNIQESNKASSEAQPAQDGKDKTDPLENKMQAGDHEAAKAAADETMKLQSEEVEEEEGVKEEEEEEEEEEETSRMVPQEPEDRLETDDQEMKRNSEETLKSVEEEMDPKAEEEAAAVGLGVPPQQDAILPEY
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
