Id: acc4095
Group: 1sens
Protein: CREB
Gene Symbol: Creb1
Protein Id: P15337
Protein Name: CREB1_RAT
PTM: phosphorylation
Site: Ser133
Site Sequence: LNDLSSDAPGVPRIEEEKSEE
Disease Category: Cardiovascular and circulatory system diseases
Disease: Infarction
Disease Subtype:
Disease Cellline:
Disease Info:
Drug: Tat-NR2B9c
Drug Info: Tat - NR2B9c is a drug that may have potential effects in relevant medical fields. Its specific functions and applications may require further research and exploration.
Effect: modulate
Effect Info: "In the cerebral ischemia model, Tat-NR2B9c can selectively and persistently enhance the phosphorylation level of CaMKIV, thereby significantly reducing the volume of cerebral infarction and exhibiting neuroprotective effects."
Note:
Score: 4.0
Pubmed(PMID): 23363435
Sentence Index:
Sentence:

Sequence & Structure:

MTMDSGADNQQSGDAAVTEAESQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPNGQTVQVHGVIQAAQPSVIQSPQVQTVQISTIAESEDSQESVDSVTDSQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSGQYIAITQGGAIQLANNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQVVVQAASGDVQTYQIRTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKSD

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets

No data.

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD
Residue Position State Disease Class PMID
S 133 U Pulmonary hypertension Phosphorylation 34635097

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: