| Id: | acc4102 |
| Group: | 1sens |
| Protein: | kras |
| Gene Symbol: | Kras |
| Protein Id: | P32883 |
| Protein Name: | RASK_MOUSE |
| PTM: | prenylation |
| Site: | unclear |
| Site Sequence: | |
| Disease Category: | Cancer |
| Disease: | Pancreatic Cancer |
| Disease Subtype: | |
| Disease Cellline: | P03 |
| Disease Info: | |
| Drug: | Sulindac |
| Drug Info: | "Sulindac is a non - steroidal anti - inflammatory drug (NSAID) used to relieve pain, swelling, and inflammation." |
| Effect: | modulate |
| Effect Info: | Sulindac inhibits pancreatic carcinogenesis by targeting AKR1B10 to suppress Kras protein isoprenylation. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 23689354 |
| Sentence Index: | 23689354_11 |
| Sentence: | Our results demonstrate that sulindac inhibits pancreatic carcinogenesis by the inhibition of Kras protein prenylation by targeting AKR1B10. |
Sequence & Structure:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQELARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCVIM
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
