| Id: | acc4117 |
| Group: | 1sens |
| Protein: | IkappaBalpha |
| Gene Symbol: | Nfkbia |
| Protein Id: | Q63746 |
| Protein Name: | IKBA_RAT |
| PTM: | phosphorylation |
| Site: | Ser32 |
| Site Sequence: | ERLVDDRHDSGLDSMKDEDYE |
| Disease Category: | Respiratory system diseases |
| Disease: | Acute Lung Injury |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | rosiglitazone? |
| Drug Info: | "Rosiglitazone is an antidiabetic drug that acts as a peroxisome proliferator-activated receptor-gamma (PPAR-γ) agonist, used to improve glycemic control in patients with type 2 diabetes." |
| Effect: | modulate |
| Effect Info: | Exposure to PQ promotes the phosphorylation and degradation of IκBα and activates NF-κB. Pretreatment with Rosiglitazone inhibits such phosphorylation and degradation in a dose-dependent manner. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 23933652 |
| Sentence Index: | 23933652_12 |
| Sentence: | "CONCLUSION: Pretreatment with rosiglitazone protects rats against PQ-induced acute lung injury by activating PPAR-gamma, inducing Nrf2 expression and inhibiting NF-kappaB activation." |
Sequence & Structure:
MFQPAGHGQDWAMEGPRDGLKKERLVDDRHDSGLDSMKDEDYEQMVKELREIRLQPQEAPLAAEPWKQQLTEDGDSFLHLAIIHEEKTLTMEVIGQVKGDLAFLNFQNNLQQTPLHLAVITNQPGIAEALLKAGCDPELRDFRGNTPLHLACEQGCLASVAVLTQTCTPQHLHSVLQATNYNGHTCLHLASIHGYLGIVEHLVTLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQTLPESEDEESYDTESEFTEDELPYDDCVFGGQRLTL
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
