| Id: | acc4122 |
| Group: | 1sens |
| Protein: | TH |
| Gene Symbol: | Th |
| Protein Id: | P04177 |
| Protein Name: | TY3H_RAT |
| PTM: | phosphorylation |
| Site: | Ser40 |
| Site Sequence: | SPRFIGRRQSLIEDARKEREA |
| Disease Category: | Systemic diseases |
| Disease: | Fatigue |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | Rg3 |
| Drug Info: | "Rg3 is a compound often extracted from ginseng, which may have various potential health - promoting effects. " |
| Effect: | modulate |
| Effect Info: | "Rg3 can induce an increase in TH phosphorylation, reverse the dopamine synthesis disorder and related behavioral changes caused by fatigue, and relieve fatigue." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 23994341 |
| Sentence Index: | 23994341_9 |
| Sentence: | Pretreatment with Rg3 significantly suppressed fatigue-induced decrease expression of TH and TH phosphorylation. |
Sequence & Structure:
MPTPSAPSPQPKGFRRAVSEQDAKQAEAVTSPRFIGRRQSLIEDARKEREAAAAAAAAAVASSEPGNPLEAVVFEERDGNAVLNLLFSLRGTKPSSLSRAVKVFETFEAKIHHLETRPAQRPLAGSPHLEYFVRFEVPSGDLAALLSSVRRVSDDVRSAREDKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYKHGEPIPHVEYTAEEIATWKEVYVTLKGLYATHACREHLEGFQLLERYCGYREDSIPQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTVYWFTVEFGLCKQNGELKAYGAGLLSSYGELLHSLSEEPEVRAFDPDTAAVQPYQDQTYQPVYFVSESFNDAKDKLRNYASRIQRPFSVKFDPYTLAIDVLDSPHTIQRSLEGVQDELHTLAHALSAIS
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
