Id: acc4125
Group: 1sens
Protein: VEGFR2
Gene Symbol: Kdr
Protein Id: P35918
Protein Name: VGFR2_MOUSE
PTM: phosphorylation
Site: Tyr951
Site Sequence: RFRQGKDYVGELSVDLKRRLD
Disease Category: Endocrine and metabolic diseases
Disease: Diabetes Mellitus
Disease Subtype: diabetic kidney disease
Disease Cellline:
Disease Info:
Drug: angiopoietin-1
Drug Info: Angiopoietin - 1 is a protein that plays a crucial role in blood vessel formation and vascular stability. It is important in physiological and pathological angiogenesis processes.
Effect: modulate
Effect Info: "Supplementation of angiopoietin-1 in diabetic mice increased the phosphorylation of Tie-2 and the level of soluble VEGFR1, accompanied by a decrease in the phosphorylation level of VEGFR2 and an increase in the phosphorylation level of endothelial nitric oxide synthase Ser(1177), along with a decrease in the phosphorylation of VEGFR2 and an increase in the phosphorylation of endothelial nitric oxide synthase Ser(1177). "
Note:
Score: 4.0
Pubmed(PMID): 24009238
Sentence Index:
Sentence:

Sequence & Structure:

MESKALLAVALWFCVETRAASVGLPGDFLHPPKLSTQKDILTILANTTLQITCRGQRDLDWLWPNAQRDSEERVLVTECGGGDSIFCKTLTIPRVVGNDTGAYKCSYRDVDIASTVYVYVRDYRSPFIASVSDQHGIVYITENKNKTVVIPCRGSISNLNVSLCARYPEKRFVPDGNRISWDSEIGFTLPSYMISYAGMVFCEAKINDETYQSIMYIVVVVGYRIYDVILSPPHEIELSAGEKLVLNCTARTELNVGLDFTWHSPPSKSHHKKIVNRDVKPFPGTVAKMFLSTLTIESVTKSDQGEYTCVASSGRMIKRNRTFVRVHTKPFIAFGSGMKSLVEATVGSQVRIPVKYLSYPAPDIKWYRNGRPIESNYTMIVGDELTIMEVTERDAGNYTVILTNPISMEKQSHMVSLVVNVPPQIGEKALISPMDSYQYGTMQTLTCTVYANPPLHHIQWYWQLEEACSYRPGQTSPYACKEWRHVEDFQGGNKIEVTKNQYALIEGKNKTVSTLVIQAANVSALYKCEAINKAGRGERVISFHVIRGPEITVQPAAQPTEQESVSLLCTADRNTFENLTWYKLGSQATSVHMGESLTPVCKNLDALWKLNGTMFSNSTNDILIVAFQNASLQDQGDYVCSAQDKKTKKRHCLVKQLIILERMAPMITGNLENQTTTIGETIEVTCPASGNPTPHITWFKDNETLVEDSGIVLRDGNRNLTIRRVRKEDGGLYTCQACNVLGCARAETLFIIEGAQEKTNLEVIILVGTAVIAMFFWLLLVIVLRTVKRANEGELKTGYLSIVMDPDELPLDERCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCKTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRGKRNEFVPYKSKGARFRQGKDYVGELSVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEASEELYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHEDPNQRPSFSELVEHLGNLLQANAQQDGKDYIVLPMSETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISHYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDSQTDSGMVLASEELKTLEDRNKLSPSFGGMMPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSDEAGLLKMVDAAVHADSGTTLRSPPV

No data.

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets

No data.

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD
Residue Position State Disease Class PMID
Y 949 D Ovarian cancer Phosphorylation 33726754
K 856 P Cancer and age-related macular degeneration Methylation 24300896
K 861 P Cancer and age-related macular degeneration Methylation 24300896
K 1041 P Cancer and age-related macular degeneration Methylation 24300896
R 817 P Cancer and age-related macular degeneration Methylation 24300896
R 1115 P Cancer and age-related macular degeneration Methylation 24300896

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: