| Id: | acc4147 |
| Group: | 1sens |
| Protein: | p38 |
| Gene Symbol: | Mapk14 |
| Protein Id: | P47811 |
| Protein Name: | MK14_MOUSE |
| PTM: | phosphorylation |
| Site: | Thr180 |
| Site Sequence: | LARHTDDEMTGYVATRWYRAP |
| Disease Category: | Cardiovascular and circulatory system diseases |
| Disease: | cardiac dysfunction |
| Disease Subtype: | Endotoxemic |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | norepinephrine |
| Drug Info: | Norepinephrine is a neurotransmitter and hormone. It plays a crucial role in the body's fight - or - flight response. |
| Effect: | modulate |
| Effect Info: | "NE inhibited p38 phosphorylation and NF–κB activation, while promoting ERK1/2 phosphorylation and c–Fos expression, thus improving endotoxin-induced cardiac dysfunction." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 24304472 |
| Sentence Index: | 24304472_10 |
| Sentence: | "In endotoxaemic mice, PE promoted myocardial ERK1/2 phosphorylation and c-Fos expression, inhibited p38 phosphorylation and IkappaBalpha degradation, reduced myocardial TNF-alpha production and prevented LPS-provoked cardiac dysfunction." |
Sequence & Structure:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
