Id: | acc4151 |
Group: | 1sens |
Protein: | AMPK |
Gene Symbol: | Prkaa1 |
Protein Id: | P54645 |
Protein Name: | AAPK1_RAT |
PTM: | phosphorylation |
Site: | Thr183 |
Site Sequence: | MMSDGEFLRTSCGSPNYAAPE |
Disease Category: | Endocrine and metabolic diseases |
Disease: | Obese |
Disease Subtype: | insulin resistance |
Disease Cellline: | |
Disease Info: | |
Drug: | rosiglitazone |
Drug Info: | Rosiglitazone is a thiazolidinedione antidiabetic drug that works by improving insulin sensitivity. |
Effect: | modulate |
Effect Info: | "Rosiglitazone inhibits the expression and secretion of PEDF in adipose tissue and liver by promoting AMPK phosphorylation, which is closely related to the improvement of insulin resistance." |
Note: | |
Score: | 4.0 |
Pubmed(PMID): | 24424059 |
Sentence Index: | 24424059_11 |
Sentence: | "However, rosiglitazone stimulated AMPK phosphorylation in fat and liver of the obese rats, whereas in vitro, when combined with compound C, the effect of rosiglitazone on PEDF was abrogated." |
Sequence & Structure:
MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSISNYRSCQRSDSDAEAQGKPSEVSLTSSVTSLDSSPVDVAPRPGSHTIEFFEMCANLIKILAQ
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.