| Id: | acc4160 |
| Group: | 1sens |
| Protein: | S6K |
| Gene Symbol: | Rps6kb1 |
| Protein Id: | Q8BSK8 |
| Protein Name: | KS6B1_MOUSE |
| PTM: | phosphorylation |
| Site: | Thr389 |
| Site Sequence: | SQFDSKFTRQTPVDSPDDSTL |
| Disease Category: | Cardiovascular and circulatory system diseases |
| Disease: | Cardiac Hypertrophy |
| Disease Subtype: | |
| Disease Cellline: | Acsl1 （H-/-）mouse |
| Disease Info: | |
| Drug: | Rapamycin |
| Drug Info: | Rapamycin is a macrolide compound that is used as an immunosuppressant and has potential applications in treating various diseases such as cancer and aging-related conditions. |
| Effect: | modulate |
| Effect Info: | Rapamycin completely blocked the enhanced ventricular S6K phosphorylation and cardiac hypertrophy. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 24631848 |
| Sentence Index: | 24631848_6 |
| Sentence: | "Rapamycin completely blocked the enhanced ventricular S6K phosphorylation and cardiac hypertrophy and attenuated the expression of hypertrophy-associated fetal genes, including alpha-skeletal actin and B-type natriuretic peptide." |
Sequence & Structure:
MRRRRRRDGFYLAPDFRHREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSGIEQMDVTVSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
