Id: acc4163
Group: 1sens
Protein: ERK1
Gene Symbol: Mapk3
Protein Id: Q63844
Protein Name: MK03_MOUSE
PTM: phosphorylation
Site: Tyr204
Site Sequence: EHDHTGFLTEYVATRWYRAPE
Disease Category: Endocrine and metabolic diseases
Disease: Diabetes Mellitus
Disease Subtype: kidney function
Disease Cellline:
Disease Info:
Drug: "VO(HB(3,5-Me2pz)3)(3,5-Me2pz)(SCN)(SCNH)2"
Drug Info: "The drug is VO(HB(3,5 - Me2pz)3)(3,5 - Me2pz)(SCN)(SCNH)2, which is likely a complex chemical compound with a specific molecular structure."
Effect: modulate
Effect Info: "The phosphorylation levels of p42/p44MAPK and Akt in diabetic mice were significantly increased. After treatment with the novel vanadium oxide complex, the insulin signaling pathway was improved, and the renal function of diabetic mice was enhanced."
Note:
Score: 4.0
Pubmed(PMID): 24636761
Sentence Index:
Sentence:

Sequence & Structure:

MAAAAAAPGGGGGEPRGTAGVVPVVPGEVEVVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRAPTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFDMELDDLPKERLKELIFQETARFQPGAPEGP

No data.

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets

No data.

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD
Residue Position State Disease Class PMID
T 203 U Squamous cell carcinoma Phosphorylation 19934324

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: