Id: acc4169
Group: 1sens
Protein: AMPKalpha
Gene Symbol: Prkaa1
Protein Id: Q5EG47
Protein Name: AAPK1_MOUSE
PTM: phosphorylation
Site: Thr172
Site Sequence: NAKIADFGLSNMMSDGEFLRT
Disease Category: Cardiovascular and circulatory system diseases
Disease: Diabetes Mellitus
Disease Subtype: mitochondrial dysfunction in type 2 diabetic heart
Disease Cellline:
Disease Info:
Drug: Tadalafil
Drug Info: "Tadalafil is a medication commonly used to treat erectile dysfunction and benign prostatic hyperplasia. It works by relaxing the blood vessels in the penis, allowing for increased blood flow. "
Effect: modulate
Effect Info: "Tadalafil also enhanced the plasma NO oxidation level in diabetic hearts, the expression of myocardial SIRT1 and PGC-1α, and the phosphorylation of eNOS, Akt, and AMPK, and alleviated mitochondrial dysfunction in type 2 diabetic hearts."
Note:
Score: 4.0
Pubmed(PMID): 24727492
Sentence Index:
Sentence:

Sequence & Structure:

MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRAAIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSISNYRSCQRSDSDAEAQGKPSDVSLTSSVTSLDSSPVDVAPRPGSHTIEFFEMCANLIKILAQ

No data.

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets

No data.

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD

No data.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: