Id: | acc4183 |
Group: | 1sens |
Protein: | Smad2 |
Gene Symbol: | Smad2 |
Protein Id: | Q62432 |
Protein Name: | SMAD2_MOUSE |
PTM: | acetylation |
Site: | Ser465 |
Site Sequence: | MGSPSVRCSSMS--------- |
Disease Category: | Cardiovascular and circulatory system diseases |
Disease: | Diabetes Mellitus |
Disease Subtype: | Diabetic Cardiomyopathy |
Disease Cellline: | H9c2 |
Disease Info: | |
Drug: | p300 inhibitor |
Drug Info: | "A p300 inhibitor is a type of drug that inhibits the activity of p300, which may have potential applications in treating certain diseases." |
Effect: | modulate |
Effect Info: | "Inhibiting p300 (using the inhibitor Curcumin or siRNA) can reduce Smad2 acetylation and TGF-β activity, thereby alleviating cardiac dysfunction." |
Note: | |
Score: | 4.0 |
Pubmed(PMID): | 24886336 |
Sentence Index: | 24886336_3 |
Sentence: | "We hypothesized that high glucose enhances the activity of the transcriptional co-activator p300, leading to the activation of TGF-beta via acetylation of Smad2; and that by inhibiting p300, TGF-beta activity will be reduced and heart failure prevented in a clinically relevant animal model of diabetic cardiomyopathy." |
Sequence & Structure:
MSSILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKKTGRLDELEKAITTQNCNTKCVTIPSTCSEIWGLSTANTVDQWDTTGLYSFSEQTRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVLPPVLVPRHTEILTELPPLDDYTHSIPENTNFPAGIEPQSNYIPETPPPGYISEDGETSDQQLNQSMDTGSPAELSPTTLSPVNHSLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDResidue | Position | State | Disease | Class | PMID |
---|---|---|---|---|---|
S | 245 | D | Obesity | Phosphorylation | 29700281 |
- | - | D | Chronic kidney disease | Phosphorylation | 23264657 |
State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.