Id: acc4183
Group: 1sens
Protein: Smad2
Gene Symbol: Smad2
Protein Id: Q62432
Protein Name: SMAD2_MOUSE
PTM: acetylation
Site: Ser465
Site Sequence: MGSPSVRCSSMS---------
Disease Category: Cardiovascular and circulatory system diseases
Disease: Diabetes Mellitus
Disease Subtype: Diabetic Cardiomyopathy
Disease Cellline: H9c2
Disease Info:
Drug: p300 inhibitor
Drug Info: "A p300 inhibitor is a type of drug that inhibits the activity of p300, which may have potential applications in treating certain diseases."
Effect: modulate
Effect Info: "Inhibiting p300 (using the inhibitor Curcumin or siRNA) can reduce Smad2 acetylation and TGF-β activity, thereby alleviating cardiac dysfunction."
Note:
Score: 4.0
Pubmed(PMID): 24886336
Sentence Index:
Sentence:

Sequence & Structure:

MSSILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKKTGRLDELEKAITTQNCNTKCVTIPSTCSEIWGLSTANTVDQWDTTGLYSFSEQTRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVLPPVLVPRHTEILTELPPLDDYTHSIPENTNFPAGIEPQSNYIPETPPPGYISEDGETSDQQLNQSMDTGSPAELSPTTLSPVNHSLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS

No data.

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets

No data.

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD
Residue Position State Disease Class PMID
S 245 D Obesity Phosphorylation 29700281
- - D Chronic kidney disease Phosphorylation 23264657

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: