PMADS

Id:	acc4204
Group:	1sens
Protein:	FOXO3
Gene Symbol:	FOXO3
Protein Id:	O43524
Protein Name:	FOXO3_HUMAN
PTM:	phosphorylation
Site:	Thr32?
Site Sequence:	EPQSRPRSCTWPLQRPELQAS
Disease Category:	Cardiovascular and circulatory system diseases
Disease:	Hypertrophic cardiomyopathy
Disease Subtype:
Disease Cellline:
Disease Info:
Drug:	YAP OE
Drug Info:	YAP OE is a drug. It may play a specific role in relevant medical or biological processes.
Effect:	modulate
Effect Info:	"YAP dephosphorylation (Ser127) and Akt1/FOXO3 phosphorylation (Ser473/Thr32) activate YAP transcriptional activity by suppressing MST1 expression, thereby promoting the development of HCM."
Note:	Non-conventional drugs
Score:	3.0
Pubmed(PMID):	25168380
Sentence Index:	25168380_3
Sentence:	"In this study, we demonstrated an up-regulation of YAP mRNA and protein levels in both HCM patient samples and transverse aortic constriction murine models as well as reduced phosphorylation of YAP at serine 127 accompanied by increased transcription of YAP-mediated genes in hypertrophic heart tissues."

Sequence & Structure:

MAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEEEDDEDDEDGGGRAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLSGGTQALLQPQQPLPPPQPGAAGGSGQPRKCSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFMRVQNEGTGKSSWWIINPDGGKSGKAPRRRAVSMDNSNKYTKSRGRAAKKKAALQTAPESADDSPSQLSKWPGSPTSRSSDELDAWTDFRSRTNSNASTVSGRLSPIMASTELDEVQDDDAPLSPMLYSSSASLSPSVSKPCTVELPRLTDMAGTMNLNDGLTENLMDDLLDNITLPPSQPSPTGGLMQRSSSFPYTTKGSGLGSPTSSFNSTVFGPSSLNSLRQSPMQTIQENKPATFSSMSHYGNQTLQDLLTSDSLSHSDVMMTQSDPLMSQASTAVSAQNSRRNVMLRNDPMMSFAAQPNQGSLVNQNLLHHQHQTQGALGGSRALSNSVSNMGLSESSSLGSAKHQQQSPVSQSMQTLSDSLSGSSLYSTSANLPVMGHEKFPSDLDLDMFNGSLECDMESIIRSELMDADGLDFNFDSLISTQNVVGLNVGNFTGAKQASSQSWVPG

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets

Small molecule

Antibody

PROTAC

Other modalities

Approved Drug

Advanced Clinical

Phase 1 Clinical

Structure with Ligand

High-Quality Ligand

High-Quality Pocket

Med-Quality Pocket

Druggable Family

Approved Drug

Advanced Clinical

Phase 1 Clinical

UniProt loc high conf

GO CC high conf

UniProt loc med conf

UniProt SigP or TMHMM

GO CC med conf

Human Protein Atlas loc

Approved Drug

Advanced Clinical

Phase 1 Clinical

Literature

UniProt Ubiquitination

Database Ubiquitination

Half-life Data

Small Molecule Binder

Approved Drug

Advanced Clinical

Phase 1 Clinical

PTM Intensity:

source: CPTAC

No intensity data of this site,
show all other sites!

FOXO3-Ser12
Cancer	Intensity
BRCA	1.448
COAD
HGSC
ccRCC	-0.214
GBM	-0.835
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC	-0.399

FOXO3-Ser215
Cancer	Intensity
BRCA	0.997
COAD
HGSC
ccRCC	-0.25
GBM	0.536
HNSC	0.096
LUAD	-1.221
LUSC	1.549
non_ccRCC	-0.465
PDAC
UCEC	-1.241

FOXO3-Ser253
Cancer	Intensity
BRCA	-0.252
COAD	0.934
HGSC	-0.476
ccRCC	-0.796
GBM	-1.043
HNSC	0.586
LUAD	1.25
LUSC	1.2
non_ccRCC	-1.739
PDAC	0.756
UCEC	-0.42

FOXO3-Ser280
Cancer	Intensity
BRCA	1.013
COAD
HGSC	-2.32
ccRCC	0.29
GBM
HNSC	0.403
LUAD	0.416
LUSC	0.374
non_ccRCC	-0.177
PDAC
UCEC	0.001

FOXO3-Ser284
Cancer	Intensity
BRCA	0.044
COAD	0.271
HGSC	-2.973
ccRCC	0.334
GBM	0.115
HNSC	0.638
LUAD	0.247
LUSC	0.308
non_ccRCC	0.38
PDAC	0.476
UCEC	0.161

FOXO3-Ser294
Cancer	Intensity
BRCA	0.707
COAD
HGSC
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC	-0.707
UCEC

FOXO3-Ser297
Cancer	Intensity
BRCA
COAD	0.707
HGSC	-0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

FOXO3-Ser299
Cancer	Intensity
BRCA
COAD	0.762
HGSC	-1.132
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC	0.37
UCEC

FOXO3-Ser311
Cancer	Intensity
BRCA	-2.162
COAD	1.528
HGSC	0.452
ccRCC	-0.252
GBM	0.305
HNSC	0.329
LUAD
LUSC	0.179
non_ccRCC
PDAC	0.267
UCEC	-0.646

FOXO3-Ser315
Cancer	Intensity
BRCA
COAD
HGSC	-1.741
ccRCC	0.739
GBM
HNSC
LUAD	0.142
LUSC	0.559
non_ccRCC
PDAC
UCEC	0.3

FOXO3-Ser411
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC
GBM	-0.707
HNSC	0.707
LUAD
LUSC
non_ccRCC
PDAC
UCEC

FOXO3-Ser412
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC	0.067
GBM	-0.844
HNSC	1.384
LUAD
LUSC
non_ccRCC
PDAC
UCEC	-0.606

FOXO3-Ser413
Cancer	Intensity
BRCA	-0.09
COAD	0.361
HGSC	-2.65
ccRCC	0.712
GBM	-0.117
HNSC	-0.258
LUAD	0.507
LUSC	0.288
non_ccRCC	1.378
PDAC	-0.12
UCEC	-0.011

FOXO3-Ser425
Cancer	Intensity
BRCA
COAD	0.413
HGSC	-1.14
ccRCC
GBM
HNSC	0.727
LUAD
LUSC
non_ccRCC
PDAC
UCEC

FOXO3-Ser428
Cancer	Intensity
BRCA
COAD	0.707
HGSC	-0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

FOXO3-Ser438
Cancer	Intensity
BRCA
COAD
HGSC	-0.707
ccRCC
GBM
HNSC
LUAD	0.707
LUSC
non_ccRCC
PDAC
UCEC

FOXO3-Ser7
Cancer	Intensity
BRCA	2.331
COAD
HGSC
ccRCC	-0.162
GBM	-1.093
HNSC
LUAD	-0.048
LUSC	-0.128
non_ccRCC	-0.346
PDAC	-0.115
UCEC	-0.44

FOXO3-Ser75
Cancer	Intensity
BRCA	1.265
COAD
HGSC
ccRCC	-1.85
GBM
HNSC
LUAD	0.569
LUSC	0.23
non_ccRCC	-0.693
PDAC	0.284
UCEC	0.195

FOXO3-Ser85
Cancer	Intensity
BRCA	1.102
COAD
HGSC
ccRCC
GBM
HNSC
LUAD	-0.85
LUSC
non_ccRCC
PDAC
UCEC	-0.252

FOXO3-Thr296
Cancer	Intensity
BRCA
COAD	0.707
HGSC	-0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

FOXO3-Thr307
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC	-0.707
GBM
HNSC	0.707
LUAD
LUSC
non_ccRCC
PDAC
UCEC

FOXO3-Thr427
Cancer	Intensity
BRCA
COAD	-0.707
HGSC	0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

FOXO3-Thr87
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC
GBM
HNSC
LUAD	0.707
LUSC
non_ccRCC
PDAC
UCEC	-0.707

PTM-Disease Association:

source: PTMD

Residue	Position	State	Disease	Class	PMID
T	32	U	Breast cancer	Phosphorylation	36797347
T	32	U	Non-small cell lung cancer	Phosphorylation	35459265

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links:

CTD
DMRdb