| Id: | acc4206 |
| Group: | 1sens |
| Protein: | YAP |
| Gene Symbol: | Yap1 |
| Protein Id: | P46938 |
| Protein Name: | YAP1_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser127 |
| Site Sequence: | QLGAVSPGTLTASGVVSGPAA |
| Disease Category: | Cardiovascular and circulatory system diseases |
| Disease: | Hypertrophic cardiomyopathy |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | YAP OE |
| Drug Info: | YAP OE is a drug. It may play a specific role in relevant medical or biological processes. |
| Effect: | modulate |
| Effect Info: | "YAP dephosphorylation (Ser127) and Akt1/FOXO3 phosphorylation (Ser473/Thr32) activate YAP transcriptional activity by suppressing MST1 expression, thereby promoting the development of HCM." |
| Note: | Non-conventional drugs |
| Score: | 3.0 |
| Pubmed(PMID): | 25168380 |
| Sentence Index: | 25168380_3 |
| Sentence: | "In this study, we demonstrated an up-regulation of YAP mRNA and protein levels in both HCM patient samples and transverse aortic constriction murine models as well as reduced phosphorylation of YAP at serine 127 accompanied by increased transcription of YAP-mediated genes in hypertrophic heart tissues." |
Sequence & Structure:
MEPAQQPPPQPAPQGPAPPSVSPAGTPAAPPAPPAGHQVVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRKLPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTASGVVSGPAAAPAAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHNDQTTTWQDPRKAMLSQLNVPAPASPAVPQTLMNSASGPLPDGWEQAMTQDGEVYYINHKNKTTSWLDPRLDPRFAMNQRITQSAPVKQPPPLAPQSPQGGVLGGGSSNQQQQIQLQQLQMEKERLRLKQQELFRQAIRNINPSTANAPKCQELALRSQLPTLEQDGGTPNAVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSIPRTPDDFLNSVDEMDTGDTISQSTLPSQQSRFPDYLEALPGTNVDLGTLEGDAMNIEGEELMPSLQEALSSEILDVESVLAATKLDKESFLTWL
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
