| Id: | acc4209 |
| Group: | 1sens |
| Protein: | AMPKalpha |
| Gene Symbol: | Prkaa1 |
| Protein Id: | Q5EG47 |
| Protein Name: | AAPK1_MOUSE |
| PTM: | phosphorylation |
| Site: | Thr172 |
| Site Sequence: | NAKIADFGLSNMMSDGEFLRT |
| Disease Category: | Endocrine and metabolic diseases |
| Disease: | Diabetes Mellitus |
| Disease Subtype: | type 2 diabetes |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | "9H-xanthene-9-carboxylic acid {2,2,2-trichloro-1-[3-(3-nitro-phenyl)-thioureido]-ethyl}-amide (Xn)" |
| Drug Info: | "The drug is 9H - xanthene - 9 - carboxylic acid {2,2,2 - trichloro - 1 - [3 - (3 - nitro - phenyl) - thioureido] - ethyl} - amide, abbreviated as (Xn)." |
| Effect: | modulate |
| Effect Info: | A single intravenous injection of Xn and Xc can stimulate the phosphorylation of AMPK in the skeletal muscle of high-fat diet-induced diabetic mice and improve glucose tolerance. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 25250787 |
| Sentence Index: | 25250787_7 |
| Sentence: | Single intravenous administration of Xn and Xc to high-fat diet-induced diabetic mice stimulated AMPK phosphorylation of skeletal muscle and improved glucose tolerance. |
Sequence & Structure:
MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRAAIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSISNYRSCQRSDSDAEAQGKPSDVSLTSSVTSLDSSPVDVAPRPGSHTIEFFEMCANLIKILAQ
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
