| Id: | acc4211 |
| Group: | 1sens |
| Protein: | SMAD1 |
| Gene Symbol: | Smad1 |
| Protein Id: | P70340 |
| Protein Name: | SMAD1_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser463 |
| Site Sequence: | MGSPHNPISSVS--------- |
| Disease Category: | Musculoskeletal system diseases |
| Disease: | Heterotopic Ossification |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | LDN-193189 |
| Drug Info: | LDN - 193189 is a drug with potential biological activity and specific effects in relevant medical or scientific research. |
| Effect: | modulate |
| Effect Info: | LDN-193189 → ↓ Phosphorylation of SMAD1/5/8 → ↓ Formation of heterotopic ossification (HO) |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 25253675 |
| Sentence Index: | 25253675_8 |
| Sentence: | "Similarly, selective inhibition of SMAD1/5/8 phosphorylation with LDN-193189 decreased HO formation and increased range of motion at the injury site in our burn model in vivo." |
Sequence & Structure:
MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGQPSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQPNSHPFPHSPNSSYPNSPGGSSSTYPHSPTSSDPGSPFQMPADTPPPAYLPPEDPMAQDGSQPMDTNMMAPPLPAEISRGDVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
