| Id: | acc4290 |
| Group: | 1sens |
| Protein: | RIP3 |
| Gene Symbol: | RIPK3 |
| Protein Id: | Q9Y572 |
| Protein Name: | RIPK3_HUMAN |
| PTM: | S-nitrosylation |
| Site: | Cys119 |
| Site Sequence: | CPRPWPLLCRLLKEVVLGMFY |
| Disease Category: | Nervous system diseases |
| Disease: | Neuronal Damage |
| Disease Subtype: | |
| Disease Cellline: | SH-SY5Y |
| Disease Info: | |
| Drug: | MK801 |
| Drug Info: | "MK801, also known as dizocilpine, is a non - competitive antagonist of the NMDA receptor. It is often used in neuroscience research. " |
| Effect: | modulate |
| Effect Info: | Drugs reduce S-nitrosylation of RIP3 and alleviate neuronal damage. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 26319693 |
| Sentence Index: | 26319693_7 |
| Sentence: | "Treatment with NMDA receptor antagonist MK801, or nNOS inhibitor 7NI, diminished RIP3 S-nitrosylation and reduced neuronal damage." |
Sequence & Structure:
MSCVKLWPSGAPAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISREVKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNMNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWLNKLNLEEPPSSVPKKCPSLTKRSRAQEEQVPQAWTAGTSSDSMAQPPQTPETSTFRNQMPSPTSTGTPSPGPRGNQGAERQGMNWSCRTPEPNPVTGRPLVNIYNCSGVQVGDNNYLTMQQTTALPTWGLAPSGKGRGLQHPPPVGSQEGPKDPEAWSRPQGWYNHSGK
Select PDB:
No data.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
