| Id: | acc4307 |
| Group: | 1sens |
| Protein: | PTEN |
| Gene Symbol: | Pten |
| Protein Id: | O54857 |
| Protein Name: | PTEN_RAT |
| PTM: | phosphorylation |
| Site: | Thr383 |
| Site Sequence: | PDHYRYSDTTDSDPENEPFDE |
| Disease Category: | Cardiovascular and circulatory system diseases |
| Disease: | Myocardial I/R Injury |
| Disease Subtype: | "Mi/R (Myocardial Ischaemia/Reperfusion) Injury, t |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | BpV |
| Drug Info: | BpV is a drug. It may have various biological activities and applications in biomedical research. |
| Effect: | modulate |
| Effect Info: | "The drug inhibits PTEN activity, reduces its phosphorylation, restores the phosphorylation of Akt, STAT3, and GSK - 3β, and reverses the loss of the protective effect of IPostC in diabetic rats." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 26666444 |
| Sentence Index: | 26666444_4 |
| Sentence: | "IPostC significantly attenuated post-ischaemic infarct size, decreased PTEN expression and further increased Akt, STAT3 and GSK-3beta phosphorylation in non-diabetic, but not in diabetic rats." |
Sequence & Structure:
MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKLMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEIDSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEASSSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHSQITKV
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
