| Id: | acc4313 |
| Group: | 1sens |
| Protein: | STAT1 |
| Gene Symbol: | Stat1 |
| Protein Id: | P42225 |
| Protein Name: | STAT1_MOUSE |
| PTM: | phosphorylation |
| Site: | Tyr701 |
| Site Sequence: | ELDDPKRTGYIKTELISVSEV |
| Disease Category: | Eye diseases |
| Disease: | Corneal Stroma |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | tofacitinib |
| Drug Info: | "Tofacitinib is a medication used to treat certain inflammatory conditions, such as rheumatoid arthritis. It works by modulating the immune system." |
| Effect: | modulate |
| Effect Info: | "The vascularized area in the tofacitinib group was significantly lower than that in the PBS group, and the immunoreactions of Gr–1, F4/80, IFN–γ, and phosphorylated STAT1 decreased significantly. It is inferred that local instillation of JAK inhibitors may contribute to the treatment of corneal inflammation." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 26689752 |
| Sentence Index: | 26689752_5 |
| Sentence: | "The immunoreactivity of Gr-1, F4/80, IFN-gamma, and phosphorylated STAT(signal transducer and activator of transcription)1 in corneal stroma was diminished significantly in the tofacitinib group." |
Sequence & Structure:
MSQWFELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAAYDVSFATIRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPVQMSMIIYNCLKEERKILENAQRFNQAQEGNIQNTVMLDKQKELDSKVRNVKDQVMCIEQEIKTLEELQDEYDFKCKTSQNREGEANGVAKSDQKQEQLLLHKMFLMLDNKRKEIIHKIRELLNSIELTQNTLINDELVEWKRRQQSACIGGPPNACLDQLQTWFTIVAETLQQIRQQLKKLEELEQKFTYEPDPITKNKQVLSDRTFLLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKSRLLVKLQESNLLTKVKCHFDKDVNEKNTVKGFRKFNILGTHTKVMNMEESTNGSLAAELRHLQLKEQKNAGNRTNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVTEPRNLSFFLNPPCAWWSQLSEVLSWQFSSVTKRGLNADQLSMLGEKLLGPNAGPDGLIPWTRFCKENINDKNFSFWPWIDTILELIKNDLLCLWNDGCIMGFISKERERALLKDQQPGTFLLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDDPKRTGYIKTELISVSEVHPSRLQTTDNLLPMSPEEFDEMSRIVGPEFDSMMSTV
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
