PMADS

Id:	acc4332
Group:	1sens
Protein:	TRPA1
Gene Symbol:	TRPA1
Protein Id:	O75762
Protein Name:	TRPA1_HUMAN
PTM:	hydroxylation
Site:	Pro394
Site Sequence:	QPYGLKNLRPEFMQMQQIKEL
Disease Category:	Nervous system diseases
Disease:	Dysesthesia
Disease Subtype:
Disease Cellline:	HEK293
Disease Info:
Drug:	dimethyloxalylglycine (DMOG)
Drug Info:	Dimethyloxalylglycine (DMOG) is a drug used in relevant research and has certain biological activities.
Effect:	modulate
Effect Info:	PHD inhibitors enhance H?O?-induced allodynic behavior by activating proline hydroxylation of TRPA1.
Note:
Score:	4.0
Pubmed(PMID):	26983498
Sentence Index:	26983498_7
Sentence:	This hypoxia-induced TRPA1 sensitisation to H2O2 was inhibited by overexpressing a catalytically-inactive mutant of prolyl hydroxylase (PHD) 2 or in a TRPA1 proline mutant resistant to PHDs.

Sequence & Structure:

MKRSLRKMWRPGEKKEPQGVVYEDVPDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCDDMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEVVLTIIRSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTEDKSCRDYYIEYNFKYLQCPLEFTKKTPTQDVIYEPLTALNAMVQNNRIELLNHPVCKEYLLMKWLAYGFRAHMMNLGSYCLGLIPMTILVVNIKPGMAFNSTGIINETSDHSEILDTTNSYLIKTCMILVFLSSIFGYCKEAGQIFQQKRNYFMDISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVYFYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNLQDPFSSPLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLAVGDIAEVQKHASLKRIAMQVELHTSLEKKLPLWFLRKVDQKSTIVYPNKPRSGGMLFHIFCFLFCTGEIRQEIPNADKSLEMEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISETEDDDSHCSFQDRFKKEQMEQRNSRWNTVLRAVKAKTHHLEP

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

Target	Drug name	MOA	Phase	Status	Disease	Source
TRPA1	MENTHOL	Transient receptor potential cation channel subfamily A member 1 opener	4	-	injury	DailyMed DailyMed DailyMed
TRPA1	MENTHOL	Transient receptor potential cation channel subfamily A member 1 opener	4	-	pain	DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed FDA DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed
TRPA1	MENTHOL	Transient receptor potential cation channel subfamily A member 1 opener	4	-	sunburn	DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed
TRPA1	MENTHOL	Transient receptor potential cation channel subfamily A member 1 opener	4	-	arthritis	DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed
TRPA1	MENTHOL	Transient receptor potential cation channel subfamily A member 1 opener	4	-	common cold	DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed
TRPA1	MENTHOL	Transient receptor potential cation channel subfamily A member 1 opener	4	-	sprain	DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed
TRPA1	MENTHOL	Transient receptor potential cation channel subfamily A member 1 opener	4	-	bronchitis	DailyMed
TRPA1	MENTHOL	Transient receptor potential cation channel subfamily A member 1 opener	4	-	muscle cramp	DailyMed
TRPA1	MENTHOL	Transient receptor potential cation channel subfamily A member 1 opener	4	-	hemorrhoid	DailyMed
TRPA1	MENTHOL	Transient receptor potential cation channel subfamily A member 1 opener	4	-	burn	DailyMed DailyMed
TRPA1	MENTHOL	Transient receptor potential cation channel subfamily A member 1 opener	4	-	frozen shoulder	DailyMed DailyMed
TRPA1	MENTHOL	Transient receptor potential cation channel subfamily A member 1 opener	4	-	Herpes Labialis	DailyMed DailyMed DailyMed
TRPA1	MENTHOL	Transient receptor potential cation channel subfamily A member 1 opener	4	-	Tendinopathy	DailyMed
TRPA1	MENTHOL	Transient receptor potential cation channel subfamily A member 1 opener	4	-	Pruritus	DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed
TRPA1	MENTHOL	Transient receptor potential cation channel subfamily A member 1 opener	4	-	Nasal congestion	DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed
TRPA1	MENTHOL	Transient receptor potential cation channel subfamily A member 1 opener	4	-	Oral ulcer	DailyMed DailyMed DailyMed
TRPA1	MENTHOL	Transient receptor potential cation channel subfamily A member 1 opener	4	-	Headache	DailyMed DailyMed
TRPA1	MENTHOL	Transient receptor potential cation channel subfamily A member 1 opener	4	-	Arthralgia	DailyMed
TRPA1	MENTHOL	Transient receptor potential cation channel subfamily A member 1 opener	4	-	Myalgia	DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed
TRPA1	MENTHOL	Transient receptor potential cation channel subfamily A member 1 opener	4	-	Back pain	DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed
TRPA1	MENTHOL	Transient receptor potential cation channel subfamily A member 1 opener	4	-	Muscle spasm	DailyMed
TRPA1	MENTHOL	Transient receptor potential cation channel subfamily A member 1 opener	4	-	Cough	DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed
TRPA1	MENTHOL	Transient receptor potential cation channel subfamily A member 1 opener	4	-	pharyngitis	DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed DailyMed
TRPA1	MENTHOL	Transient receptor potential cation channel subfamily A member 1 opener	4	-	bursitis	DailyMed
TRPA1	MENTHOL	Transient receptor potential cation channel subfamily A member 1 opener	4	-	tendinitis	DailyMed

Note: Only show clinically investigational or approved drugs with protein targets.

Protein Tractability:

source: Open Targets

Small molecule

Antibody

PROTAC

Other modalities

Approved Drug

Advanced Clinical

Phase 1 Clinical

Structure with Ligand

High-Quality Ligand

High-Quality Pocket

Med-Quality Pocket

Druggable Family

Approved Drug

Advanced Clinical

Phase 1 Clinical

UniProt loc high conf

GO CC high conf

UniProt loc med conf

UniProt SigP or TMHMM

GO CC med conf

Human Protein Atlas loc

Approved Drug

Advanced Clinical

Phase 1 Clinical

Literature

UniProt Ubiquitination

Database Ubiquitination

Half-life Data

Small Molecule Binder

Approved Drug

Advanced Clinical

Phase 1 Clinical

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD

No data.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links:

CTD
DMRdb