| Id: | acc4342 |
| Group: | 1sens |
| Protein: | AMPKalpha |
| Gene Symbol: | Prkaa1 |
| Protein Id: | Q5EG47 |
| Protein Name: | AAPK1_MOUSE |
| PTM: | phosphorylation |
| Site: | Thr172 |
| Site Sequence: | NAKIADFGLSNMMSDGEFLRT |
| Disease Category: | Endocrine and metabolic diseases |
| Disease: | Iodine Deficiency |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | metformin |
| Drug Info: | "Metformin is a widely - used oral medication for treating type 2 diabetes, which helps control blood sugar levels." |
| Effect: | modulate |
| Effect Info: | "The AMPK activator metformin can activate AMPK and inhibit mTOR activity, thereby suppressing ID-induced microvascular activation." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 27035650 |
| Sentence Index: | 27035650_7 |
| Sentence: | "In vitro, although ID increased p70S6K phosphorylationation, the ID-stimulated hypoxia-inducible factor/VEGF pathway was inhibited by rapamycin." |
Sequence & Structure:
MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRAAIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSISNYRSCQRSDSDAEAQGKPSDVSLTSSVTSLDSSPVDVAPRPGSHTIEFFEMCANLIKILAQ
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
