| Id: | acc4343 |
| Group: | 1sens |
| Protein: | p70S6K |
| Gene Symbol: | Rps6kb1 |
| Protein Id: | Q8BSK8 |
| Protein Name: | KS6B1_MOUSE |
| PTM: | phosphorylation |
| Site: | Thr389 |
| Site Sequence: | SQFDSKFTRQTPVDSPDDSTL |
| Disease Category: | Endocrine and metabolic diseases |
| Disease: | Iodine Deficiency |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | rapamycin |
| Drug Info: | Rapamycin is a macrolide compound that is used as an immunosuppressant and has potential applications in treating various diseases such as cancer and aging-related conditions. |
| Effect: | modulate |
| Effect Info: | "In RET/PTC3 thyroid cancer model mice, rapamycin inhibited the increases in p70S6K phosphorylation, thyroid blood flow, and VEGF - A expression induced by iodine deficiency (ID)." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 27035650 |
| Sentence Index: | 27035650_7 |
| Sentence: | "In vitro, although ID increased p70S6K phosphorylationation, the ID-stimulated hypoxia-inducible factor/VEGF pathway was inhibited by rapamycin." |
Sequence & Structure:
MRRRRRRDGFYLAPDFRHREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSGIEQMDVTVSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
