| Id: | acc4345 |
| Group: | 1sens |
| Protein: | eNOS |
| Gene Symbol: | Nos3 |
| Protein Id: | Q62600 |
| Protein Name: | NOS3_RAT |
| PTM: | phosphorylation |
| Site: | Ser1177 |
| Site Sequence: | VTSRIRTQSFSLQERQLRGAV |
| Disease Category: | Cardiovascular and circulatory system diseases |
| Disease: | Pulmonary Hypertension |
| Disease Subtype: | Pulmonary Arterial Hypertension |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | metformin |
| Drug Info: | "Metformin is a widely - used oral medication for treating type 2 diabetes, which helps control blood sugar levels." |
| Effect: | modulate |
| Effect Info: | "The drug metformin upregulates the expression of PGC - 1α, which in turn affects the phosphorylation level of the Ser1177 site of eNOS, and improves endothelial dysfunction associated with chronic hypoxia - induced pulmonary arterial hypertension (PAH)." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 27084848 |
| Sentence Index: | 27084848_7 |
| Sentence: | "Hypoxia-induced PGC-1alpha inhibited the oxidative metabolism and mitochondrial function, whereas sustained PGC-1alpha decreased reactive oxygen species (ROS) formation, mitochondrial swelling, and NF-kappaB activation and increased ATP formation and endothelial nitric oxide synthase (eNOS) phosphorylationation." |
Sequence & Structure:
MGNLKSVGQEPGPPCGLGLGLGLGLCGKQGPASPAPEPSQAPVPPSPTRPAPDHSPPLTRPPDGPKFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCLGSLVFPRKLQSRPTQGPSPTEQLLGQARDFINQYYNSIKRSGSQAHEQRLQEVEAEVVATGTYQLRESELVFGAKQAWRNAPRCVGRIQWGKLQVFDARDCRTAQEMFTYICNHIKYATNRGNLRSAITVFPQRYAGRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEPPELFTLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMSSEIGMRDLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINVAVLYSYQLAKVTIVDHHAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPWKGSAAKGTGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQLGRLFRKAFDPRVLCMDEYDVVSLEHEALVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSSPRPEQHKSYKIRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHFCAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQAACETFCVGEDAKAAARDIFSPKRSWKRQRYRLSTQAESLQLLPRLTHVHRRKMFQATILSVENLQSSKSTRATILVRLDTGSQEGLQYQPGDHIGVCPPNRPGLVEALLSRVEDPPPSTEPVAVEQLEKGSPGGPPPGWVRDPRLPPCTLRQALTYFLDITSPPSPRLLRLLSTLAEESSEQQELEALSQDPRRYEEWKWFRCPTLLEVLEQFPSVALPAPLILTQLPLLQPRYYSVSSAPSAHPGEIHLTVAVLAYRTQDGLGPLHYGVCSTWMSQLKAGDPVPCFIRGAPSFRLPPDPNLPCILVGPGTGIAPFRGFWQDRLHDIEIKGLQPAPMTLVFGCRCSQLDHLYRDEVLDAQQRGVFGQVLTAFSRDPGSPKTYVQDLLRTELAAEVHRVLCLEQGHMFVCGDVTMATSVLQTVQRILATEGSMELDEAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERQLRGAVPWSFDPPTQETPGS
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
