| Id: | acc4356 |
| Group: | 1sens |
| Protein: | Fyn |
| Gene Symbol: | Fyn |
| Protein Id: | Q62844 |
| Protein Name: | FYN_RAT |
| PTM: | S-nitrosylation |
| Site: | Cys498 |
| Site Sequence: | QDCPISLHELMIHCWKKDPEE |
| Disease Category: | Cardiovascular and circulatory system diseases |
| Disease: | Cerebral Ischemia |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | GSNO |
| Drug Info: | "GSNO is a drug that plays important roles in various physiological processes, such as regulating blood pressure and having antioxidant effects." |
| Effect: | modulate |
| Effect Info: | "Fyn can be S-nitrosylated both in vitro and in vivo, and inhibiting S-nitrosylation can exert a neuroprotective effect on cerebral ischemia/reperfusion (I/R) injury." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 27420046 |
| Sentence Index: | 27420046_5 |
| Sentence: | "Application of GSNO, 7-nitroindazole (7-NI, an inhibitor of neuronal NOS) and hydrogen maleate (MK-801, the N-methyl-d-aspartate receptor (NMDAR) antagonist) could decrease the S-nitrosylation and phosphorylation of Fyn induced by cerebral ischemia/reperfusion (I/R)." |
Sequence & Structure:
MGCVQCKDKEAAKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQGFLEDYFTATEPQYQPGENL
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
