| Id: | acc4357 |
| Group: | 1sens |
| Protein: | Smad2 |
| Gene Symbol: | Smad2 |
| Protein Id: | Q62432 |
| Protein Name: | SMAD2_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser465 |
| Site Sequence: | MGSPSVRCSSMS--------- |
| Disease Category: | Endocrine and metabolic diseases |
| Disease: | Hepatic Steatosis |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | Vaccination |
| Drug Info: | Vaccination is a medical procedure that involves administering a vaccine to stimulate the immune system and provide protection against specific diseases. |
| Effect: | modulate |
| Effect Info: | "In the CCl?-induced liver injury model, vaccine intervention → ↓ expression of α-SMA, ↓ phosphorylation of Smad2 → inhibition of HSCs activation → inhibition of liver fibrosis progression" |
| Note: | Non-conventional drugs |
| Score: | 3.0 |
| Pubmed(PMID): | 27562139 |
| Sentence Index: | 27562139_5 |
| Sentence: | "CCl4 intoxication-induced hepatic stellate cell activation was inhibited by the vaccination, as indicated by decreased alpha-smooth muscle actin expression and Smad2 phosphorylation." |
Sequence & Structure:
MSSILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKKTGRLDELEKAITTQNCNTKCVTIPSTCSEIWGLSTANTVDQWDTTGLYSFSEQTRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVLPPVLVPRHTEILTELPPLDDYTHSIPENTNFPAGIEPQSNYIPETPPPGYISEDGETSDQQLNQSMDTGSPAELSPTTLSPVNHSLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMD| Residue | Position | State | Disease | Class | PMID |
|---|---|---|---|---|---|
| S | 245 | D | Obesity | Phosphorylation | 29700281 |
| - | - | D | Chronic kidney disease | Phosphorylation | 23264657 |
State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
