| Id: | acc4383 |
| Group: | 1sens |
| Protein: | PTEN |
| Gene Symbol: | Pten |
| Protein Id: | O08586 |
| Protein Name: | PTEN_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser380 |
| Site Sequence: | DNEPDHYRYSDTTDSDPENEP |
| Disease Category: | Endocrine and metabolic diseases |
| Disease: | Insulin Resistance |
| Disease Subtype: | "Insulin Resistance, Obesity" |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | Calorie restriction |
| Drug Info: | "Calorie restriction refers to a dietary approach that reduces calorie intake without causing malnutrition, which is thought to have potential health - promoting and longevity - enhancing effects." |
| Effect: | modulate |
| Effect Info: | CR enhanced the insulin sensitivity of the liver in GDM offspring and improved lipid metabolism by inhibiting PTEN phosphorylation. |
| Note: | Non-conventional drugs |
| Score: | 3.0 |
| Pubmed(PMID): | 28024145 |
| Sentence Index: | 28024145_11 |
| Sentence: | "Moreover, the specific decrease in PTEN activation and increase in Akt phosphorylation in livers of GDM offspring with CR improved insulin sensitivity and lipid metabolism." |
Sequence & Structure:
MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEIDSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEASSSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHSQITKV
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
