| Id: | acc4388 |
| Group: | 1sens |
| Protein: | Akt |
| Gene Symbol: | Akt1 |
| Protein Id: | P47196 |
| Protein Name: | AKT1_RAT |
| PTM: | phosphorylation |
| Site: | Ser473 |
| Site Sequence: | ERRPHFPQFSYSASGTA---- |
| Disease Category: | Nervous system diseases |
| Disease: | Neuronal Degeneration |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | CHIP overexpression |
| Drug Info: | CHIP overexpression refers to the excessive expression of the CHIP protein. It may play important roles in cellular processes such as protein quality control. |
| Effect: | modulate |
| Effect Info: | "Overexpression of CHIP leads to reduced phosphorylation of eIF2α and AKT, preventing neuronal degeneration." |
| Note: | Non-conventional drugs |
| Score: | 3.0 |
| Pubmed(PMID): | 28153090 |
| Sentence Index: | 28153090_5 |
| Sentence: | "We show that CHIP overexpression prevented neuronal degeneration in both cases and led to a decrease of both eIF2alpha (serine 51) and AKT (serine 473) phosphorylation, as well as reduced amounts of ubiquitinated proteins following hypoxia or ischemia." |
Sequence & Structure:
MNDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVEQRESPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKRQEEETMDFRSGSPSDNSGAEEMEVALAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPTQRLGGGSEDAKEIMQHRFFANIVWQDVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMD| Residue | Position | State | Disease | Class | PMID |
|---|---|---|---|---|---|
| S | 473 | D | Major depressive disorder | Phosphorylation | 16959794 |
| S | 473 | D | Type 2 diabetes | Phosphorylation | 34057658 ; 36374861 |
| S | 473 | U | Status epilepticus | Phosphorylation | 35562960 |
State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
