| Id: | acc4389 |
| Group: | 1sens |
| Protein: | eIF2alpha |
| Gene Symbol: | Eif2s1 |
| Protein Id: | P68101 |
| Protein Name: | IF2A_RAT |
| PTM: | phosphorylation |
| Site: | Ser51 |
| Site Sequence: | IEGMILLSELSRRRIRSINKL |
| Disease Category: | Nervous system diseases |
| Disease: | Neuronal Degeneration |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | CHIP overexpression |
| Drug Info: | CHIP overexpression refers to the excessive expression of the CHIP protein. It may play important roles in cellular processes such as protein quality control. |
| Effect: | modulate |
| Effect Info: | "Overexpression of CHIP leads to reduced phosphorylation of eIF2α and AKT, preventing neuronal degeneration." |
| Note: | Non-conventional drugs |
| Score: | 3.0 |
| Pubmed(PMID): | 28153090 |
| Sentence Index: | 28153090_5 |
| Sentence: | "We show that CHIP overexpression prevented neuronal degeneration in both cases and led to a decrease of both eIF2alpha (serine 51) and AKT (serine 473) phosphorylation, as well as reduced amounts of ubiquitinated proteins following hypoxia or ischemia." |
Sequence & Structure:
MPGLSCRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMILLSELSRRRIRSINKLIRIGRNECVVVIRVDKEKGYIDLSKRRVSPEEAIKCEDKFTKSKTVYSILRHVAEVLEYTKDEQLESLFQRTAWVFDDKYKRPGYGAYDAFKHAVSDPSILDSLDLNEDEREVLINNINRRLTPQAVKIRADIEVACYGYEGIDAVKEALRAGLNCSTETMPIKINLIAPPRYVMTTTTLERTEGLSVLNQAMAVIKEKIEEKRGVFNVQMEPKVVTDTDETELARQLERLERENAEVDGDDDAEEMEAKAED
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
