| Id: | acc4392 |
| Group: | 1sens |
| Protein: | Tau |
| Gene Symbol: | Mapt |
| Protein Id: | P10637 |
| Protein Name: | TAU_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser396 |
| Site Sequence: | RPTLGSSDPLIKPSSPAVSPE |
| Disease Category: | Endocrine and metabolic diseases |
| Disease: | Diabetes Mellitus |
| Disease Subtype: | STZ induced diabetic mice |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | Folic acid |
| Drug Info: | Folic acid is a B - vitamin that helps the body make new cells and is important for pregnant women to prevent birth defects. |
| Effect: | modulate |
| Effect Info: | Folic acid can reduce tau phosphorylation in diabetic mice by regulating PP2A methylation. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 28422052 |
| Sentence Index: | 28422052_15 |
| Sentence: | Folic acid can reduce tau phosphorylation by regulating PP2A methylation in diabetic mice. |
Sequence & Structure:
MADPRQEFDTMEDHAGDYTLLQDQEGDMDHGLKESPPQPPADDGAEEPGSETSDAKSTPTAEDVTAPLVDERAPDKQAAAQPHTEIPEGITAEEAGIGDTPNQEDQAAGHVTQGRREGQAPDLGTSDWTRQQVSSMSGAPLLPQGLREATCQPSGTRPEDIEKSHPASELLRRGPPQKEGWGQDRLGSEEEVDEDLTVDESSQDSPPSQASLTPGRAAPQAGSGSVCGETASVPGLPTEGSVPLPADFFSKVSAETQASQPEGPGTGPMEEGHEAAPEFTFHVEIKASTPKEQDLEGATVVGVPGEEQKAQTQGPSVGKGTKEASLQEPPGKQPAAGLPGRPVSRVPQLKARVASKDRTGNDEKKAKTSTPSCAKAPSHRPCLSPTRPTLGSSDPLIKPSSPAVSPEPATSPKHVSSVTPRNGSPGTKQMKLKGADGKTGAKIATPRGAASPAQKGTSNATRIPAKTTPSPKTPPGSGEPPKSGERSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSASKSRLQTAPVPMPDLKNVRSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
