| Id: | acc4414 |
| Group: | 1sens |
| Protein: | FOXO3a |
| Gene Symbol: | Foxo3 |
| Protein Id: | Q9WVH4 |
| Protein Name: | FOXO3_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser253 |
| Site Sequence: | KAPRRRAVSMDNSNKYTKSRG |
| Disease Category: | Urinary and reproductive system diseases |
| Disease: | Ovarian Damage |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | melatonin and ghrelin |
| Drug Info: | Melatonin is a hormone that regulates sleep - wake cycles. | Ghrelin is a peptide hormone that stimulates appetite. |
| Effect: | modulate |
| Effect Info: | Melatonin and ghrelin can synergistically alleviate cisplatin-induced ovarian damage by regulating the phosphorylation state of FOXO3a and enhancing its binding ability to the p27Kip1 promoter. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 28658519 |
| Sentence Index: | 28658519_0 |
| Sentence: | Synergistic effect of melatonin and ghrelin in preventing cisplatin-induced ovarian damage via regulation of FOXO3a phosphorylation and binding to the p27Kip1 promoter in primordial follicles. |
Sequence & Structure:
MAEAPASPVPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEEDDDEDDEDGGGRASSAMVIGGGVSSTLGSGLLLEDSAMLLAPGGQDLGSGPASAAGALSGGTPTQLQPQQPLPQPQPGAAGGSGQPRKCSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFMRVQNEGTGKSSWWIINPDGGKSGKAPRRRAVSMDNSNKYTKSRGRAAKKKAALQAAPESADDSPSQLSKWPGSPTSRSSDELDAWTDFRSRTNSNASTVSGRLSPILASTELDDVQDDDGPLSPMLYSSSASLSPSVSKPCTVELPRLTDMAGTMNLNDGLAENLMDDLLDNIALPPSQPSPPGGLMQRGSSFPYTAKSSGLGSPTGSFNSTVFGPSSLNSLRQSPMQTIQENRPATFSSVSHYGNQTLQDLLASDSLSHSDVMMTQSDPLMSQASTAVSAQNARRNVMLRNDPMMSFAAQPTQGSLVNQNLLHHQHQTQGALGGSRALSNSVSNMGLSDSSSLGSAKHQQQSPASQSMQTLSDSLSGSSLYSASANLPVMGHDKFPSDLDLDMFNGSLECDMESIIRSELMDADGLDFNFDSLISTQNVVGLNVGNFTGAKQASSQSWVPG
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
