| Id: | acc4417 |
| Group: | 1sens |
| Protein: | PTEN |
| Gene Symbol: | Pten |
| Protein Id: | O08586 |
| Protein Name: | PTEN_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser380 |
| Site Sequence: | DNEPDHYRYSDTTDSDPENEP |
| Disease Category: | Urinary and reproductive system diseases |
| Disease: | Ovarian Damage |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | cisplatin |
| Drug Info: | Cisplatin is a widely used chemotherapy drug that is effective in treating various types of cancers. |
| Effect: | modulate |
| Effect Info: | "Cisplatin treatment significantly increased the phosphorylation level of PTEN, while the combined use of melatonin and auxin could significantly inhibit this phosphorylation, effectively preventing cisplatin-induced follicle destruction." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 28658519 |
| Sentence Index: | 28658519_0 |
| Sentence: | Synergistic effect of melatonin and ghrelin in preventing cisplatin-induced ovarian damage via regulation of FOXO3a phosphorylation and binding to the p27Kip1 promoter in primordial follicles. |
Sequence & Structure:
MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEIDSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEASSSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHSQITKV
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
