| Id: | acc4419 |
| Group: | 1sens |
| Protein: | AMPK |
| Gene Symbol: | Prkaa2 |
| Protein Id: | Q09137 |
| Protein Name: | AAPK2_RAT |
| PTM: | phosphorylation |
| Site: | Thr172 |
| Site Sequence: | MMSDGEFLRTSCGSPNYAAPE |
| Disease Category: | Cardiovascular and circulatory system diseases |
| Disease: | Myocardial Infarction |
| Disease Subtype: | diabetes mellitus |
| Disease Cellline: | H9c2 |
| Disease Info: | |
| Drug: | A-769662 |
| Drug Info: | A-769662 is a drug. It may have potential effects on specific physiological processes. |
| Effect: | decrease |
| Effect Info: | "After myocardial ischemia-reperfusion in diabetic rats, the phosphorylation level of AMPK decreased. The AMPK activator A–769662 (6.0 mg/kg) restored the cardioprotection of IPO. In vitro experiments showed that the combined use of A–769662 and post-hypoxic treatment reduced the hypoxia-reperfusion injury of H9c2 cells under high glucose conditions." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 28765969 |
| Sentence Index: | 28765969_6 |
| Sentence: | "In diabetic rats the myocardial infarct size, and creatine kinase-MB and malondialdehyde release, were increased compared with non-diabetic rats, concomitant with increased cardiac dysfunction and decreased cardiac superoxide dismutase activity, AMPK phosphorylation and autophagy following IR." |
Sequence & Structure:
MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEVEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAQMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSIATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPTGSFMDDMAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSVDSSTAENHSLSGSLTGSLTGSTLSSASPRLGSHTMDFFEMCASLITALAR
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMD| Residue | Position | State | Disease | Class | PMID |
|---|---|---|---|---|---|
| T | 172 | D | Type 2 diabetes | Phosphorylation | 33848515 |
State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
