Id: acc4422
Group: 1sens
Protein: Akt
Gene Symbol: Akt1
Protein Id: P47196
Protein Name: AKT1_RAT
PTM: phosphorylation
Site: Thr308
Site Sequence: GIKDGATMKTFCGTPEYLAPE
Disease Category: Endocrine and metabolic diseases
Disease: Obese
Disease Subtype: metabolic syndrome
Disease Cellline:
Disease Info:
Drug: everolimus
Drug Info: Everolimus is an immunosuppressant drug used to prevent organ transplant rejection and treat certain types of cancer.
Effect: modulate
Effect Info: Everolimus treatment reduced Akt Thr308 phosphorylation in the hearts of DS/obese rats and alleviated the disease symptoms.
Note:
Score: 4.0
Pubmed(PMID): 28805979
Sentence Index:
Sentence:

Sequence & Structure:

MNDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVEQRESPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKRQEEETMDFRSGSPSDNSGAEEMEVALAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPTQRLGGGSEDAKEIMQHRFFANIVWQDVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA

No data.

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets

No data.

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD
Residue Position State Disease Class PMID
T 308 D Obesity Phosphorylation 16267124

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: